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1
FK506: a novel immunosuppressive agent. Characteristics of binding and uptake by human lymphocytes.FK506：一种新型免疫抑制剂。人淋巴细胞的结合与摄取特性。
Transplantation. 1988 Sep;46(3):453-5. doi: 10.1097/00007890-198809000-00025.
2
Increased cyclosporine uptake by cells pretreated with FK506 and evidence for binding of both drugs to a common intracellular protein.经FK506预处理的细胞对环孢素的摄取增加，且有证据表明两种药物都与一种共同的细胞内蛋白质结合。
Transplant Proc. 1989 Feb;21(1 Pt 1):1050-2.
3
Investigations of neurotrophic inhibitors of FK506 binding protein via Monte Carlo simulations.通过蒙特卡罗模拟对FK506结合蛋白的神经营养抑制剂进行研究。
J Med Chem. 1998 Oct 8;41(21):3928-39. doi: 10.1021/jm980062o.
4
FK-506, a potent novel immunosuppressive agent, binds to a cytosolic protein which is distinct from the cyclosporin A-binding protein, cyclophilin.FK-506是一种强效新型免疫抑制剂，它与一种胞质蛋白结合，这种蛋白不同于环孢素A结合蛋白亲环蛋白。
J Immunol. 1989 Sep 1;143(5):1580-3.
5
Surfactant protein A (SP-A)-tacrolimus complexes have a greater anti-inflammatory effect than either SP-A or tacrolimus alone on human macrophage-like U937 cells.表面活性蛋白 A（SP-A）-他克莫司复合物对人巨噬细胞样 U937 细胞的抗炎作用大于 SP-A 或他克莫司单独作用。
Eur J Pharm Biopharm. 2011 Apr;77(3):384-91. doi: 10.1016/j.ejpb.2010.12.013. Epub 2010 Dec 21.
6
Effect of a new immunosuppressive agent, FK506, on human lymphocyte responses in vitro. I. Inhibition of expression of alloantigen-activated suppressor cells, as well as induction of alloreactivity.
Transplantation. 1989 Feb;47(2):351-6. doi: 10.1097/00007890-198902000-00034.
7
Combination of hydrotropic nicotinamide with nanoparticles for enhancing tacrolimus percutaneous delivery.亲水性烟酰胺与纳米颗粒联合用于增强他克莫司经皮递送
Int J Nanomedicine. 2016 Aug 19;11:4037-50. doi: 10.2147/IJN.S108545. eCollection 2016.
8
Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation.新型免疫抑制剂FK506。对克隆化T细胞激活的体外作用。
J Immunol. 1987 Sep 15;139(6):1797-803.
9
Metabolic profile of a new immunosuppressive agent, oxisuran: binding, RE stimulation, drug interaction.新型免疫抑制剂奥昔舒仑的代谢概况：结合、RE刺激、药物相互作用
J Reticuloendothel Soc. 1973 Oct;14(4):387-97.
10
Effect of a new immunosuppressive agent, FK506, on human lymphocyte responses in vitro. II. Inhibition of the production of IL-2 and gamma-IFN, but not B cell-stimulating factor 2.新型免疫抑制剂FK506对人淋巴细胞体外反应的影响。II. 抑制白细胞介素-2和γ-干扰素的产生，但不抑制B细胞刺激因子2。
Transplantation. 1989 Feb;47(2):356-9. doi: 10.1097/00007890-198902000-00035.

引用本文的文献

1
Micro and nanoparticle drug delivery systems for preventing allotransplant rejection.用于预防同种异体移植排斥反应的微米和纳米颗粒药物递送系统。
Clin Immunol. 2015 Sep;160(1):24-35. doi: 10.1016/j.clim.2015.04.013. Epub 2015 May 1.
2
Clinical pharmacokinetics of tacrolimus.他克莫司的临床药代动力学
Clin Pharmacokinet. 1995 Dec;29(6):404-30. doi: 10.2165/00003088-199529060-00003.
3
Hepatic transplantation at the University of Pittsburgh: new horizons and paradigms after 30 years of experience.匹兹堡大学的肝移植：30年经验后的新视野与范式
Clin Transpl. 1994:133-56.
4
Single-center experience with primary orthotopic liver transplantation with FK 506 immunosuppression.FK506免疫抑制下原位肝移植的单中心经验。
Ann Surg. 1994 Sep;220(3):297-308; discussion 308-9. doi: 10.1097/00000658-199409000-00006.
5
Inhibition of murine B-lymphocyte proliferation by the novel immunosuppressive drug FK-506.新型免疫抑制药物FK-506对小鼠B淋巴细胞增殖的抑制作用。
Immunology. 1989 Nov;68(3):434-5.
6
Current status of renal transplantation.肾移植的现状
West J Med. 1990 Jun;152(6):687-96.

本文引用的文献

1
IN VITRO IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 ON HUMAN T LYMPHOCYTE ALLOACTIVATION.FR 900506对人T淋巴细胞同种异体激活的体外免疫抑制作用。
Surg Res Commun. 1987;1:315-323.
2
Depletion of monocytes from human peripheral blood mononuclear leukocytes: comparison of the sephadex G-10 column method with other commonly used techniques.从人外周血单个核白细胞中去除单核细胞：Sephadex G-10柱法与其他常用技术的比较。
J Immunol Methods. 1980;32(1):11-29. doi: 10.1016/0022-1759(80)90113-1.
3
Binding of cyclosporine by human lymphocytes and phospholipid vesicles.
J Immunol. 1983 Aug;131(2):712-8.
4
Uptake and nature of the intracellular binding of cyclosporin A in a murine thymoma cell line, BW5147.环孢菌素A在小鼠胸腺瘤细胞系BW5147中的细胞内结合摄取及性质
J Immunol. 1984 Jun;132(6):3064-70.
5
Kinetics of uptake and intracellular binding of Cyclosporine A in RAJI cells, in vitro.体外RAJI细胞中环孢素A的摄取及细胞内结合动力学
Biochem Pharmacol. 1986 Dec 1;35(23):4261-6. doi: 10.1016/0006-2952(86)90704-5.
6
Effect of a new immunosuppressive agent, FK 506, on heterotopic cardiac allotransplantation in the rat.新型免疫抑制剂FK 506对大鼠异位心脏同种异体移植的影响。
Transplant Proc. 1987 Feb;19(1 Pt 2):1284-6.
7
FK-506 enhances cyclosporine uptake by peripheral blood lymphocytes.FK-506可增强外周血淋巴细胞对环孢素的摄取。
Transplant Proc. 1987 Oct;19(5 Suppl 6):45-9.
8
Immunosuppressive effect of FK-506 on in vitro lymphocyte alloactivation: synergism with cyclosporine A.FK-506对体外淋巴细胞同种异体激活的免疫抑制作用：与环孢素A的协同作用。
Transplant Proc. 1987 Oct;19(5 Suppl 6):40-4.
9
Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation.新型免疫抑制剂FK506。对克隆化T细胞激活的体外作用。
J Immunol. 1987 Sep 15;139(6):1797-803.

FK506: a novel immunosuppressive agent. Characteristics of binding and uptake by human lymphocytes.

作者信息

Warty V, Diven W, Cadoff E, Todo S, Starzl T, Sanghvi A

机构信息

Department of Pathology, University of Pittsburgh School of Medicine, PA 15261.

出版信息

Transplantation. 1988 Sep;46(3):453-5. doi: 10.1097/00007890-198809000-00025.

DOI:10.1097/00007890-198809000-00025
PMID:2458643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2954623/
Abstract
摘要