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新型免疫抑制药物FK-506对小鼠B淋巴细胞增殖的抑制作用。

Inhibition of murine B-lymphocyte proliferation by the novel immunosuppressive drug FK-506.

作者信息

Walliser P, Benzie C R, Kay J E

机构信息

Biochemistry Laboratory, School of Biological Sciences, University of Sussex, Brighton.

出版信息

Immunology. 1989 Nov;68(3):434-5.

PMID:2480331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1385461/
Abstract

The novel immunosuppressive drug FK-506 inhibits both cell-mediated and humoral immunity in vivo and suppresses T-lymphocyte activation at nanamolar concentrations in vitro. We report here that FK-506 also inhibits the in vitro proliferation of murine B lymphocytes induced by goat antimouse IgM (GaMIgM), although it does not affect the induction of proliferation by bacterial lipopolysaccharide (LPS). The action of FK-506 on B-lymphocyte proliferation thus resembles that of cyclosporin A, further strengthening the correlation between the action of the two immunosuppressive drugs previously reported for T-lymphocyte activation.

摘要

新型免疫抑制药物FK-506在体内可抑制细胞介导的免疫和体液免疫，并在体外以纳摩尔浓度抑制T淋巴细胞活化。我们在此报告，FK-506也可抑制山羊抗小鼠IgM（GaMIgM）诱导的小鼠B淋巴细胞的体外增殖，尽管它不影响细菌脂多糖（LPS）诱导的增殖。因此，FK-506对B淋巴细胞增殖的作用类似于环孢素A，进一步加强了先前报道的这两种免疫抑制药物对T淋巴细胞活化作用之间的相关性。

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本文引用的文献

1
Inhibition of proliferation of a murine myeloma cell line and mitogen-stimulated B lymphocytes by the antibiotic amphotericin B (Fungizone).抗生素两性霉素B（制霉菌素）对小鼠骨髓瘤细胞系和丝裂原刺激的B淋巴细胞增殖的抑制作用。
Immunology. 1982 Sep;47(1):115-21.
2
Effects of cyclosporin A on the immune system of the mouse. I. Evidence for a direct selective effect of cyclosporin A on B cells responding to anti-immunoglobulin antibodies.环孢素A对小鼠免疫系统的影响。I. 环孢素A对响应抗免疫球蛋白抗体的B细胞有直接选择性作用的证据。
Eur J Immunol. 1982 Dec;12(12):1018-22. doi: 10.1002/eji.1830121207.
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Cyclosporin as a probe for different modes of lymphocyte activation.
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The cyclosporin-A-sensitive event in lymphocyte activation.淋巴细胞激活过程中对环孢素A敏感的事件。
Ann Inst Pasteur Immunol. 1987 Jul-Aug;138(4):622-5. doi: 10.1016/s0769-2625(87)80134-4.
5
Inhibition of T-lymphocyte activation by the immunosuppressive drug FK-506.免疫抑制药物FK-506对T淋巴细胞激活的抑制作用。
Immunology. 1989 Aug;67(4):473-7.
6
Effect of a new immunosuppressive agent, FK506, on human lymphocyte responses in vitro. I. Inhibition of expression of alloantigen-activated suppressor cells, as well as induction of alloreactivity.
Transplantation. 1989 Feb;47(2):351-6. doi: 10.1097/00007890-198902000-00034.
7
Spleen lymphocyte populations and expression of activation markers in rats treated with the potent new immunosuppressive agent FK-506.用强效新型免疫抑制剂FK - 506处理的大鼠脾脏淋巴细胞群体及活化标志物的表达
Immunology. 1988 Sep;65(1):153-5.
8
FK506: a novel immunosuppressive agent. Characteristics of binding and uptake by human lymphocytes.FK506：一种新型免疫抑制剂。人淋巴细胞的结合与摄取特性。
Transplantation. 1988 Sep;46(3):453-5. doi: 10.1097/00007890-198809000-00025.
9
FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.FK-506，一种从链霉菌中分离出的新型免疫抑制剂。II. FK-506的体外免疫抑制作用。
J Antibiot (Tokyo). 1987 Sep;40(9):1256-65. doi: 10.7164/antibiotics.40.1256.
10
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J Antibiot (Tokyo). 1987 Sep;40(9):1249-55. doi: 10.7164/antibiotics.40.1249.

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