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非词重复——瑞典语中特定语言障碍的一个临床指标,与父母的语言相关问题有关。

Nonword repetition--a clinical marker for specific language impairment in Swedish associated with parents' language-related problems.

作者信息

Kalnak Nelli, Peyrard-Janvid Myriam, Forssberg Hans, Sahlén Birgitta

机构信息

Department of Women's and Children's Health, Astrid Lindgren Children's Hospital, Karolinska Institutet, Stockholm, Sweden.

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.

出版信息

PLoS One. 2014 Feb 24;9(2):e89544. doi: 10.1371/journal.pone.0089544. eCollection 2014.

Abstract

First, we explore the performance of nonword repetition (NWR) in children with specific language impairment (SLI) and typically developing children (TD) in order to investigate the accuracy of NWR as a clinical marker for SLI in Swedish-speaking school-age children. Second, we examine the relationship between NWR, family aggregation, and parental level of education in children with SLI. A sample of 61 children with SLI, and 86 children with TD, aged 8-12 years, were administered an NWR test. Family aggregation, measured as the prevalence of language and/or literacy problems (LLP) in parents of the children with SLI, was based on family history interviews. The sensitivity and specificity of nonword repetition was analyzed in a binary logistic regression, cut-off values were established with ROC curves, and positive and negative likelihood ratios reported. Results from the present study show that NWR distinguishes well between Swedish-speaking school-children with and without SLI. We found 90.2% sensitivity and 97.7% specificity at a cut-off level of -2 standard deviations for binary scoring of nonwords. Differences between the SLI and TD groups showed large effect sizes for the two scoring measures binary (d = 2.11) and percent correct consonants (PCC) (d = 1.79). The children with SLI were split into two subgroups: those with no parents affected with LLP (n = 12), and those with one or both parents affected (n = 49). The subgroup consisting of affected parents had a significantly lower score on NWR binary (p = .037), and there was a great difference between the subgroups (d = 0.7). When compared to the TD group, the difference from the subgroup with affected parents was almost one standard deviation larger (d = 2.47) than the difference from the TD to the subgroup consisting of non-affected parents (d = 1.57). Our study calls for further exploration of the complex interaction between family aggregation, language input, and phenotypes of SLI.

摘要

首先,我们探究特定语言障碍(SLI)儿童和发育正常儿童(TD)的非词重复(NWR)表现,以研究NWR作为瑞典语学龄儿童SLI临床标志物的准确性。其次,我们研究SLI儿童的NWR、家族聚集性和父母教育水平之间的关系。对61名8至12岁的SLI儿童和86名TD儿童进行了NWR测试。家族聚集性以SLI儿童父母中语言和/或读写问题(LLP)的患病率来衡量,基于家族史访谈得出。在二元逻辑回归中分析非词重复的敏感性和特异性,用ROC曲线确定临界值,并报告阳性和阴性似然比。本研究结果表明,NWR能很好地区分有和没有SLI的瑞典语学龄儿童。对于非词的二元评分,我们发现在-2标准差的临界水平下,敏感性为90.2%,特异性为97.7%。SLI组和TD组之间的差异在二元评分(d = 2.11)和正确辅音百分比(PCC)(d = 1.79)这两种评分方法上显示出较大的效应量。SLI儿童被分为两个亚组:父母未受LLP影响的儿童(n = 12)和父母一方或双方受影响的儿童(n = 49)。父母受影响的亚组在NWR二元评分上得分显著更低(p = 0.037),且亚组之间存在很大差异(d = 0.7)。与TD组相比,与父母受影响亚组的差异比与父母未受影响亚组的差异几乎大一个标准差(d = 2.47,d = 1.57)。我们的研究呼吁进一步探索家族聚集性、语言输入和SLI表型之间的复杂相互作用。

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