Maggio-Price L, Emerson C L, Hinds T R, Vincenzi F F, Hammond W R
Department of Pathology, School of Medicine, University of Washington, Seattle 98195.
Am J Vet Res. 1988 Jul;49(7):1020-5.
Three Beagles with chronic anemia and reticulocytosis were studied. The dogs originated from a large breeding colony and appeared clinically normal with the exception of splenomegaly. The PCV ranged from 30 to 39% (normal, 46 to 56%), with reticulocyte indices of 2.3 to 9.9. Red blood cells were morphologically normal, and examination of marrow aspirates revealed erythroid hyperplasia. Shortened chromium-51 RBC life-spans (7.2 to 15.4 days in anemic dogs; 22.2 to 25.2 days in control dogs) documented a hemolytic anemia. Acquired causes of hemolytic anemia were ruled out. Red blood cells had normal glycolytic enzyme activities, no evidence of unstable or abnormal hemoglobin, and had altered osmotic fragility curves. The breeding of 2 anemic dogs resulted in offspring with anemia and reticulocytosis. Polyacrylamide gel electrophoresis revealed no abnormalities in RBC membrane cytoskeletal proteins in all anemic adult dogs and in 3 offspring.
对三只患有慢性贫血和网织红细胞增多症的比格犬进行了研究。这些犬来自一个大型繁殖群体，除脾肿大外，临床上表现正常。血细胞比容范围为30%至39%（正常为46%至56%），网织红细胞指数为2.3至9.9。红细胞形态正常，骨髓穿刺检查显示红系增生。铬-51红细胞寿命缩短（贫血犬为7.2至15.4天；对照犬为22.2至25.2天）证实为溶血性贫血。排除了获得性溶血性贫血的病因。红细胞具有正常的糖酵解酶活性，没有不稳定或异常血红蛋白的证据，并且渗透脆性曲线发生了改变。两只贫血犬繁殖的后代出现贫血和网织红细胞增多症。聚丙烯酰胺凝胶电泳显示，所有贫血成年犬及其3只后代的红细胞膜细胞骨架蛋白均无异常。
