Randolph J F, Center S A, Kallfelz F A, Blue J T, Dodds W J, Harvey J W, Paglia D E, Walsh K M, Shelly S M
Am J Vet Res. 1986 Mar;47(3):687-95.
Nonspherocytic hemolytic anemia, characterized by marked reticulocytosis, hepatosplenomegaly, hemosiderosis of reticuloendothelial organs and bone marrow myelofibrosis, and osteosclerosis, was diagnosed in 5 related Poodles. The unremitting anemia was clinically evident by 1 year of age, and was fatal as early as 3 years of age. Despite intense diagnostic endeavors including RBC fragility studies, RBC enzyme assays, and hemoglobin electrophoresis, the cause of this nonspherocytic hemolytic anemia remains to be determined.
5只相关的贵宾犬被诊断出患有非球形红细胞溶血性贫血，其特征为显著的网织红细胞增多、肝脾肿大、网状内皮器官和骨髓的含铁血黄素沉着以及骨硬化。这种持续性贫血在1岁时临床症状明显，最早在3岁时就会致命。尽管进行了包括红细胞脆性研究、红细胞酶测定和血红蛋白电泳在内的深入诊断工作，但这种非球形红细胞溶血性贫血的病因仍有待确定。
