Ancheta Irma B, Battie Cynthia A, Richard Dan, Ancheta Christine V, Borja-Hart Nancy, Volgman Annabelle S, Conley Yvette
School of Nursing, University of North Florida, 1 UNF Drive, Jacksonville, FL 32224, USA.
University of South Florida, Tampa, FL 33612, USA.
Nurs Res Pract. 2014;2014:328954. doi: 10.1155/2014/328954. Epub 2014 Jan 23.
The Trp719Arg allele of KIF6 rs20455, a putative risk factor for CHD especially in those with elevated low-density lipoprotein cholesterol (LDL-C), was investigated in Filipino-American women (FAW, n = 235) participating in health screenings in four cities. The rs20455 genotype of each subject was determined by a multiplex assay using a Luminex-OLA procedure. The risk allele Trp719Arg was present in 77% of the subjects. The genotype distribution was 23% Trp/Trp, 51% Arg/Trp, and 26% Arg/Arg. Genotype did not predict the presence of CHD risk factors. Moreover, LDL-C, HDL-C, and triglycerides mean values did not vary as a function of genotype. However, those with the Arg/Arg genotype on statin medication exhibited a significantly higher mean triglycerides level (P < 0.01). Approximately 60% of participants regardless of genotype exhibited LDL-C levels ≥100 mg/dL but were not taking medication. Approximately 43% of those with the Trp719Arg risk allele on statins exhibited elevated LDL-C levels. Our study suggests that the Trp719Arg allele of KIF 6 rs20455 is common among Filipino-American women; thus, even with borderline LDL-C levels would benefit from statin treatment. Secondly, many participants did not exhibit guideline recommended LDL-C levels including many who were on statin drugs.
KIF6基因rs20455位点的Trp719Arg等位基因是冠心病的一个潜在危险因素，尤其是在那些低密度脂蛋白胆固醇（LDL-C）升高的人群中。我们对参与四个城市健康筛查的菲律宾裔美国女性（FAW，n = 235）进行了该等位基因的研究。通过使用Luminex-OLA程序的多重分析来确定每个受试者的rs20455基因型。77%的受试者存在风险等位基因Trp719Arg。基因型分布为23% Trp/Trp、51% Arg/Trp和26% Arg/Arg。基因型不能预测冠心病危险因素的存在。此外，LDL-C、HDL-C和甘油三酯的平均值不会因基因型而变化。然而，服用他汀类药物的Arg/Arg基因型者甘油三酯平均水平显著更高（P < 0.01）。无论基因型如何，约60%的参与者LDL-C水平≥100mg/dL，但未服用药物。服用他汀类药物且携带Trp719Arg风险等位基因的参与者中，约43%的人LDL-C水平升高。我们的研究表明，KIF6基因rs20455位点的Trp719Arg等位基因在菲律宾裔美国女性中很常见；因此，即使LDL-C水平处于临界值，他汀类治疗也会使其受益。其次，许多参与者未表现出指南推荐的LDL-C水平，包括许多正在服用他汀类药物的人。
