El-Masry Hosny M A, Nasr Ahmed A M, Al Kabeer Ashraf M, Amin H H, Eldeeb Hussein M H
Department of Pediatrics .
J Matern Fetal Neonatal Med. 2015 Jan;28(1):41-5. doi: 10.3109/14767058.2014.900039. Epub 2014 Apr 9.
The mechanisms of tissue injury in respiratory distress syndrome (RDS) have not been completely elucidated but the involvement of oxidative damage due to reactive oxygen species (ROS) is important in the pathogenesis of preterm labor and RDS.
To assess the oxidative status in preterms with and without RDS and in their mothers.
Measuring and comparing concentrations of serum nitric oxide (NO), and erythrocytic activities of some antioxidant enzymes in blood of 20 preterms with RDS and 20 preterms without and their mothers, respectively.
Our results confirm significant elevation of mean levels of serum NO and reduced mean levels of erythrocytic activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT), in RDS preterms and their mothers compared with controls and their mothers. A significant positive correlations were found between maternal and preterm serum NO (r=0.3 & 0.6) and erythrocytic activity of SOD (r=0.5 & 0.4) for RDS and control groups, respectively. In addition, a significant negative correlations were found between NO and SOD in all groups.
The existence of oxygen metabolites and lipid peroxidation was significantly more obvious in RDS preterms and in their mothers than those without.
呼吸窘迫综合征（RDS）的组织损伤机制尚未完全阐明，但活性氧（ROS）导致的氧化损伤在早产和RDS的发病机制中具有重要作用。
评估患和未患RDS的早产儿及其母亲的氧化状态。
分别测定并比较20例患RDS的早产儿、20例未患RDS的早产儿及其母亲血液中血清一氧化氮（NO）浓度以及某些抗氧化酶的红细胞活性。
我们的结果证实，与对照组及其母亲相比，患RDS的早产儿及其母亲血清NO平均水平显著升高，抗氧化酶超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）和过氧化氢酶（CAT）的红细胞活性平均水平降低。RDS组和对照组中，母亲与早产儿血清NO（r=0.3和0.6）以及SOD红细胞活性（r=0.5和0.4）之间分别存在显著正相关。此外，所有组中NO与SOD之间均存在显著负相关。
与未患RDS的早产儿及其母亲相比，患RDS的早产儿及其母亲体内氧代谢产物和脂质过氧化的存在明显更为显著。
