NMIMS, School of Pharmacy & Technology Management, Shirpur (Maharashtra), India.
Department of Molecular Biology ICMR-National Institute for Research in Environmental Health, Bhopal (MP), India.
Nanomedicine. 2018 Oct;14(7):2023-2050. doi: 10.1016/j.nano.2018.05.021. Epub 2018 Jun 23.
Over the recent couple of decades, pharmaceutical field has embarked most phenomenal noteworthy achievements in the field of medications as well as drug delivery. The rise of Nanotechnology in this field has reformed the existing drug delivery for targeting, diagnostic, remedial applications and patient monitoring. The convincing usage of nanotechnology in the conveyance of medications that prompts an extension of novel lipid-based nanocarriers and non-liposomal systems has been discussed. Present review deals with the late advances and updates in lipidic nanocarriers, their formulation strategies, challenging aspects, stability profile, clinical applications alongside commercially available products and products under clinical trials. This exploration may give a complete idea viewing the lipid based nanocarriers as a promising choice for the formulation of pharmaceutical products, the challenges looked by the translational process of lipid-based nanocarriers and the combating methodologies to guarantee the headway of these nanocarriers from bench to bedside.
在最近几十年中，制药领域在药物和药物输送领域取得了最显著的成就。纳米技术在该领域的兴起改变了现有的靶向、诊断、治疗应用和患者监测药物输送方式。本文讨论了纳米技术在促使新型基于脂质的纳米载体和非脂质体系统药物输送方面的令人信服的应用。本综述涉及脂质纳米载体的最新进展和更新，包括其制剂策略、挑战性方面、稳定性概况、临床应用以及市售产品和临床试验产品。通过这种探索，可以全面了解基于脂质的纳米载体作为药物制剂的有前途的选择，了解基于脂质的纳米载体转化过程中面临的挑战以及确保这些纳米载体从实验室到临床顺利推进的应对方法。
