小白菊——一种抗血栓药物？

Feverfew--an antithrombotic drug?

作者信息

Loesche W, Mazurov A V, Voyno-Yasenetskaya T A, Groenewegen W A, Heptinstall S, Repin V S

机构信息

Institute of Pathological Biochemistry, Medical Academy of Erfurt, GDR.

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1988;115(1-2):181-4.

PMID:2459017

Abstract

The effects of an extract of the plant feverfew on the interaction of platelets with surfaces coated with human collagens of type III and IV (CIII, CIV), and on the integrity of the endothelial cell (EC) monolayer in perfused rabbit aorta were studied. It was shown that feverfew extract (FE) inhibited the deposition of [51Cr]-labelled platelets on both CIII and CIV in a dose-dependent way. Similar concentrations of FE were needed to inhibit formation of surface-bound aggregates in CIII and platelet spreading on CIV in both platelet-rich plasma and GFP. When aorta segments were perfused in situ with a physiological salt solution, the addition of FE to the solution protected the EC monolayer from spontaneous injury. The results indicate that feverfew may have antithrombotic potential in addition to its claimed benefit in fever, migraine and arthritis.

摘要

研究了小白菊提取物对血小板与包被有III型和IV型人胶原蛋白（CIII、CIV）的表面之间相互作用的影响，以及对灌注兔主动脉中内皮细胞（EC）单层完整性的影响。结果表明，小白菊提取物（FE）以剂量依赖的方式抑制[51Cr]标记的血小板在CIII和CIV上的沉积。在富血小板血浆和绿色荧光蛋白中，抑制CIII表面结合聚集体的形成以及血小板在CIV上的铺展需要相似浓度的FE。当用生理盐溶液原位灌注主动脉段时，向溶液中添加FE可保护EC单层免受自发性损伤。结果表明，除了其在发热、偏头痛和关节炎方面声称的益处外，小白菊可能还具有抗血栓形成的潜力。