小白菊提取物可抑制血小板和多形核白细胞中的颗粒分泌。

Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes.

作者信息

Heptinstall S, White A, Williamson L, Mitchell J R

出版信息

Lancet. 1985 May 11;1(8437):1071-4. doi: 10.1016/s0140-6736(85)92371-2.

Abstract

Extracts of feverfew (Tanacetum parthenium) inhibited secretory activity in blood platelets and polymorphonuclear leucocytes (PMNs). Release of serotonin from platelets induced by various aggregating agents (adenosine diphosphate, adrenaline, sodium arachidonate, collagen, and U46619) was inhibited. Platelet aggregation was consistently inhibited but thromboxane synthesis was not. Feverfew also inhibited release of vitamin B12-binding protein from PMNs induced by the secretagogues formyl-methionyl-leucyl-phenylalanine, sodium arachidonate, and zymosan-activated serum. Feverfew did not inhibit the secretion induced in platelets or PMNs by the calcium ionophore A23187. The pattern of the effects of the feverfew extracts on platelets is different from that obtained with other inhibitors of platelet aggregation and the effect on PMNs is more pronounced than has been obtained with very high concentrations of non-steroidal anti-inflammatory agents.

摘要

小白菊（菊蒿）提取物可抑制血小板和多形核白细胞（PMNs）的分泌活性。由各种聚集剂（二磷酸腺苷、肾上腺素、花生四烯酸钠、胶原蛋白和U46619）诱导的血小板中5-羟色胺的释放受到抑制。血小板聚集始终受到抑制，但血栓素的合成未受抑制。小白菊还可抑制由促分泌剂甲酰甲硫氨酰亮氨酰苯丙氨酸、花生四烯酸钠和酵母聚糖激活血清诱导的PMNs中维生素B12结合蛋白的释放。小白菊不抑制钙离子载体A23187诱导的血小板或PMNs的分泌。小白菊提取物对血小板的作用模式与其他血小板聚集抑制剂不同，对PMNs的作用比用非常高浓度的非甾体抗炎药所获得的作用更明显。