J Clin Invest. 2014 Mar;124(3):943-52. doi: 10.1172/JCI73316. Epub 2014 Mar 3.
Emerging research on the roles of stromal cells in modulating adaptive immune responses has included a new focus on lymphatic endothelial cells (LECs). LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes. LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. This Review summarizes the emergent evidence that LECs are important in maintaining peripheral tolerance, limiting and resolving effector T cell responses, and modulating leukocyte function.
越来越多的研究表明基质细胞在调节适应性免疫反应中发挥作用，其中新的关注点是淋巴管内皮细胞（LEC）。LEC 可能是与外周抗原、细胞因子、危险信号以及从外周组织迁移至淋巴结的免疫细胞最先发生直接接触的细胞。LEC 可以调节树突状细胞功能，在 MHC I 类和 MHC II 类分子上向 T 细胞呈递抗原，并表达免疫调节细胞因子和受体，这表明它们在适应性免疫中的作用远比之前认识到的更为广泛。本综述总结了新出现的证据，表明 LEC 在维持外周耐受、限制和解决效应 T 细胞应答以及调节白细胞功能方面发挥着重要作用。
