Helpap B
Institute of Pathology, Municipal Hospital, Singen, West Germany.
Histopathology. 1988 Aug;13(2):203-11. doi: 10.1111/j.1365-2559.1988.tb02025.x.
Specimens of prostate obtained for histopathological and cytological examination by urethral resection and 'punch' biopsies showing carcinoma, atypical and typical hyperplasia were re-examined with regard to the number, size and localization of nucleoli. With increasing degrees of malignancy the number and size of the nucleoli increased and the position of the nucleolus shifted to the periphery of the nucleus. In the cells in typical and slightly atypical prostatic hyperplasia there were few nucleoli which were localized to the centre of the nucleus. In moderately atypical hyperplasia there were intermediate locations, while in severe atypical hyperplasia and 'borderline' malignant cases there was a distinct shift towards the periphery of the nucleus as well as an increase in the number of nucleoli in each nucleus. It is suggested that careful analysis of the number and localization of nucleoli can be helpful in the analysis of the differential diagnosis between carcinoma and atypical hyperplasia of the prostate, which can be difficult in histopathological and cytopathological material.
通过尿道切除术和“穿刺”活检获取的用于组织病理学和细胞学检查的前列腺标本，显示有癌、非典型和典型增生，对其核仁的数量、大小和定位进行了重新检查。随着恶性程度的增加，核仁的数量和大小增加，核仁的位置移至细胞核周边。在典型和轻度非典型前列腺增生的细胞中，核仁很少，位于细胞核中央。在中度非典型增生中，核仁位置居中，而在重度非典型增生和“临界”恶性病例中，核仁明显向细胞核周边移位，且每个细胞核中的核仁数量增加。有人认为，仔细分析核仁的数量和定位有助于前列腺癌与非典型增生的鉴别诊断分析，而这在组织病理学和细胞病理学材料中可能会很困难。
