Diamond M P, DeCherney A H, Linsky C B, Cunningham T, Constantine B
Department of Obstetrics and Gynecology, Yale University, New Haven, Connecticut.
Int J Fertil. 1988 Jul-Aug;33(4):278-82.
The ability of solutions of carboxymethylcellulose (CMC) and 32% dextran 70 to reduce postoperative adhesion formation was examined using a rabbit uterine-horn scrape model. Utilization of 50 mL of 32% dextran 70 did not reduce adhesion formation compared with control rabbits. However, intraperitoneal instillation of CMC significantly reduced postoperative adhesion formation. An inverse correlation was established between either the concentration of CMC employed (1%, 2%, and 3%) or the volume of 2% CMC employed (20, 30, 40, and 50 mL) and the extent of adhesion formation. It is concluded that in this animal model CMC, but not 32% dextran 70, was able to retard postoperative adhesion formation.
使用兔子宫角刮擦模型，研究了羧甲基纤维素（CMC）溶液和32%右旋糖酐70减少术后粘连形成的能力。与对照兔相比，使用50 mL 32%右旋糖酐70并未减少粘连形成。然而，腹腔内注入CMC可显著减少术后粘连形成。所使用的CMC浓度（1%、2%和3%）或2% CMC的体积（20、30、40和50 mL）与粘连形成程度之间呈负相关。得出的结论是，在该动物模型中，CMC能够延缓术后粘连形成，而32%右旋糖酐70则不能。
