Graebe R A, Oelsner G, Cornelison T L, Pan S B, Haseltine F P, DeCherney A H
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510.
Microsurgery. 1989;10(1):53-5. doi: 10.1002/micr.1920100110.
A study was designed to test various high-molecular-weight solutions in the prevention of postoperative intraabdominal adhesions. The bicornuate rat uterus was used as the surgical model, and 80 mature white female rats underwent surgical injury of the right uterine horn. The rats were randomly divided into 5 groups: groups A, B, and C received 5 ml intraperitoneally of chondroitin sulfate, sodium carboxymethylcellulose, and 32% dextran 70, respectively; group D was treated with microsurgical repair; and group E, the control, received no therapy. The animals were killed postoperatively, and the adhesions were scored. Significantly better results in adhesion prevention were demonstrated in the sodium carboxymethylcellulose group vs. the other groups, except in group A where the difference was not significant.
一项研究旨在测试各种高分子量溶液在预防术后腹腔内粘连方面的效果。采用双角大鼠子宫作为手术模型，80只成熟的白色雌性大鼠接受了右子宫角的手术损伤。大鼠被随机分为5组：A组、B组和C组分别腹腔注射5毫升硫酸软骨素、羧甲基纤维素钠和32%的右旋糖酐70；D组采用显微外科修复治疗；E组作为对照组，不接受任何治疗。术后处死动物，并对粘连情况进行评分。结果显示，羧甲基纤维素钠组在预防粘连方面的效果明显优于其他组，但与A组相比差异不显著。
