Oelsner G, Graebe R A, Pan S B, Haseltine F P, Barnea E R, Fakih H, DeCherney A H
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510.
J Reprod Med. 1987 Nov;32(11):812-4.
A study was designed to test chondroitin sulphate and other high-molecular-weight solutions, using the rabbit uterus as the surgical model, in the prevention of postoperative adhesions. Eighty-five mature white female New Zealand rabbits underwent surgical injury of each uterine horn, with surgical repair of the left horn only in all animals using 9-0 nylon. The rabbits were randomly divided into five groups: groups A, B and C received 25 mL of chondroitin sulphate, sodium carboxymethylcellulose or 32% dextran 70, respectively. The remaining two groups received either 50 mL of normal saline (D) or no solution (E). Postoperatively the animals were killed, and the adhesions were carefully scored. The results clearly demonstrated the superiority of chondroitin sulphate as an intraperitoneal treatment for the prevention of postoperative adhesions (P less than .001 vs. carboxymethyl cellulose, dextran, saline and control).
一项研究旨在以兔子宫作为手术模型，测试硫酸软骨素和其他高分子量溶液预防术后粘连的效果。85只成年白色新西兰雌性兔每只子宫角均接受手术损伤，所有动物仅对左侧子宫角用9-0尼龙线进行手术修复。这些兔子被随机分为五组：A组、B组和C组分别接受25 mL硫酸软骨素、羧甲基纤维素钠或32%右旋糖酐70。其余两组分别接受50 mL生理盐水（D组）或不接受任何溶液（E组）。术后处死动物，并仔细对粘连情况进行评分。结果清楚地表明，硫酸软骨素作为腹腔内治疗预防术后粘连具有优越性（与羧甲基纤维素、右旋糖酐、生理盐水和对照组相比，P<0.001）。
