Rorbach Joanna, Bobrowicz Agnieszka, Pearce Sarah, Minczuk Michal
Mitochondrial Genetics Group, MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK,
Methods Mol Biol. 2014;1125:211-27. doi: 10.1007/978-1-62703-971-0_18.
Polyadenylation is a posttranscriptional modification present throughout all the kingdoms of life with important roles in regulation of RNA stability, translation, and quality control. Functions of polyadenylation in prokaryotic and organellar RNA metabolism are still not fully characterized, and poly(A) tails appear to play contrasting roles in different systems. Here we present a general overview of the polyadenylation process and the factors involved in its regulation, with an emphasis on the diverse functions of 3' end modification in the control of gene expression in different biological systems.
聚腺苷酸化是一种存在于所有生命王国中的转录后修饰，在RNA稳定性、翻译和质量控制的调节中发挥着重要作用。聚腺苷酸化在原核生物和细胞器RNA代谢中的功能仍未完全明确，并且聚（A）尾巴在不同系统中似乎发挥着相反的作用。在这里，我们对聚腺苷酸化过程及其调控所涉及的因素进行了概述，重点介绍了3'端修饰在不同生物系统中基因表达控制方面的多种功能。
