Takal Mustafa Kemal, Baykal Cem, Başer Eralp, Kaya Mustafa Derda, Dursun Polat, Ozen Ozlem, Haberal Asuman Nihan, Ayhan Ali
Department of Obstetrics and Gynecology, Division of Gynecological Oncology, Başkent University School of Medicine, Ankara, Turkey.
Department of Pathology, Başkent University School of Medicine, Ankara, Turkey.
J Turk Ger Gynecol Assoc. 2013 Sep 1;14(3):130-5. doi: 10.5152/jtgga.2013.02679. eCollection 2013.
To assess the relationship between Aquaporin-1 (AQP1) expression and clinicopathological variables in serous epithelial ovarian cancer (EOC).
Serous EOC cases treated in our institution between January 2007 and December 2009 were included in the study. A semi-quantitative immunohistochemical method was used to determine AQP1 expression levels, intratumoral microvessel density (IMD) and AQP1/IMD ratios. The relationship between these parameters and clinicopathological variables were assessed. P values less than 0.05 was considered statistically significant.
A total of 55 cases of serous EOC were included in the study. AQP1 was strongly expressed in the membranes of microvessels and small vessels within all tumor tissues. In a few cases, AQP1 expression was also observed in the membrane of interstitial cells and in individual tumor cells. A positive correlation was detected between preoperative CA125 levels and the expression of AQP1 (R: 0.277, p<0.05). AQP1 expression was similar between FIGO stage I-II and FIGO stage III-IV cases (p > 0.05). A significant relationship did not exist between AQP1 expression and FIGO stage, lymph node metastasis or ascites volume (p>0.05).
In this study, AQP1 expression did not have a significant association with important clinicopathological variables in serous EOC. Future studies are needed to determine AQP1 expression in other histological types of EOC.
评估水通道蛋白-1（AQP1）表达与浆液性上皮性卵巢癌（EOC）临床病理变量之间的关系。
本研究纳入了2007年1月至2009年12月在我院接受治疗的浆液性EOC病例。采用半定量免疫组织化学方法测定AQP1表达水平、肿瘤内微血管密度（IMD）及AQP1/IMD比值。评估这些参数与临床病理变量之间的关系。P值小于0.05被认为具有统计学意义。
本研究共纳入55例浆液性EOC病例。AQP1在所有肿瘤组织内的微血管和小血管膜上呈强表达。在少数病例中，间质细胞膜和个别肿瘤细胞中也观察到AQP1表达。术前CA125水平与AQP1表达之间存在正相关（R：0.277，p<0.05）。FIGO I-II期和FIGO III-IV期病例的AQP1表达相似（p>0.05）。AQP1表达与FIGO分期、淋巴结转移或腹水体积之间不存在显著关系（p>0.）。
在本研究中，AQP1表达与浆液性EOC的重要临床病理变量无显著关联。未来需要开展研究以确定其他组织学类型EOC中的AQP1表达情况。
