银屑病斑块中γ干扰素诱导蛋白IP-10的检测
Detection of a gamma interferon-induced protein IP-10 in psoriatic plaques.
作者信息
Gottlieb A B, Luster A D, Posnett D N, Carter D M
机构信息
Laboratory of Immunology, Rockefeller University, New York.
出版信息
J Exp Med. 1988 Sep 1;168(3):941-8. doi: 10.1084/jem.168.3.941.
Abstract
The pathologic features of psoriatic plaques are inflammation and increased epidermal turnover. IP-10, a cytokine the expression of which is induced by gamma-interferon, is a member of a family of soluble mediators with inflammatory and growth-promoting activities. IP-10 protein was detected in keratinocytes and the dermal infiltrate from active psoriatic plaques using an affinity-purified rabbit anti-IP-10 antibody in immunoperoxidase studies. Successful treatment of active plaques decreased IP-10 expression in plaques. These results were corroborated by Northern blot analysis with an IP-10 cDNA probe. We have previously detected activated T cells and HLA-DR keratinocytes in active psoriatic plaques. Since IP-10 is detected in delayed cellular immune responses, the present study further points to the role of ongoing cellular immune responses in the pathogenesis of psoriasis.
摘要
银屑病斑块的病理特征为炎症和表皮更替增加。IP-10是一种由γ干扰素诱导表达的细胞因子，属于具有炎症和促生长活性的可溶性介质家族成员。在免疫过氧化物酶研究中，使用亲和纯化的兔抗IP-10抗体在活性银屑病斑块的角质形成细胞和真皮浸润物中检测到了IP-10蛋白。活性斑块的成功治疗降低了斑块中IP-10的表达。用IP-10 cDNA探针进行的Northern印迹分析证实了这些结果。我们之前在活性银屑病斑块中检测到了活化的T细胞和HLA-DR角质形成细胞。由于在迟发型细胞免疫反应中检测到了IP-10，本研究进一步指出持续的细胞免疫反应在银屑病发病机制中的作用。
相似文献
1
Detection of a gamma interferon-induced protein IP-10 in psoriatic plaques.银屑病斑块中γ干扰素诱导蛋白IP-10的检测
J Exp Med. 1988 Sep 1;168(3):941-8. doi: 10.1084/jem.168.3.941.
2
Immunologic mechanisms in psoriasis.银屑病中的免疫机制。
J Invest Dermatol. 1990 Nov;95(5 Suppl):18S-19S. doi: 10.1111/1523-1747.ep12505675.
3
The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin.γ干扰素诱导蛋白（IP - 10）在人类皮肤迟发型免疫反应中的表达
J Exp Med. 1987 Oct 1;166(4):1098-108. doi: 10.1084/jem.166.4.1098.
4
Expression of HLA-DR molecules by keratinocytes, and presence of Langerhans cells in the dermal infiltrate of active psoriatic plaques.角质形成细胞HLA - DR分子的表达，以及在活动性银屑病斑块真皮浸润中朗格汉斯细胞的存在。
J Exp Med. 1986 Oct 1;164(4):1013-28. doi: 10.1084/jem.164.4.1013.
5
6
Detection of the interferon-gamma-induced protein 10 in psoriasiform dermatitis of acquired immunodeficiency syndrome.获得性免疫缺陷综合征银屑病样皮炎中γ干扰素诱导蛋白10的检测
Arch Dermatol. 1990 Nov;126(11):1457-61.
7
Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes.催乳素可增强干扰素-γ诱导人角质形成细胞产生CXC配体9（CXCL9）、CXCL10和CXCL11。
Endocrinology. 2007 May;148(5):2317-25. doi: 10.1210/en.2006-1639. Epub 2007 Jan 25.
8
Detection of interferon-gamma mRNA in psoriatic epidermis by polymerase chain reaction.
J Dermatol Sci. 1991 Mar;2(2):106-11. doi: 10.1016/0923-1811(91)90019-t.
9
Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell-derived cytokines.特应性皮炎和银屑病患者的角质形成细胞在对T细胞衍生细胞因子的反应中表现出独特的趋化因子产生谱。
J Allergy Clin Immunol. 2001 May;107(5):871-7. doi: 10.1067/mai.2001.114707.
10
Epidermal interferon-gamma inducible protein-10 (IP-10) and monokine induced by gamma-interferon (Mig) but not IL-8 mRNA expression is associated with epidermotropism in cutaneous T cell lymphomas.表皮γ-干扰素诱导蛋白10（IP-10）和γ-干扰素诱导的单核细胞趋化蛋白（Mig）而非白细胞介素8（IL-8）的信使核糖核酸（mRNA）表达与皮肤T细胞淋巴瘤的亲表皮性相关。
J Invest Dermatol. 1998 Aug;111(2):222-6. doi: 10.1046/j.1523-1747.1998.00263.x.
引用本文的文献
1
The Central Roles of Keratinocytes in Coordinating Skin Immunity.角质形成细胞在皮肤免疫协调中的核心作用。
J Invest Dermatol. 2024 Nov;144(11):2377-2398. doi: 10.1016/j.jid.2024.06.1280. Epub 2024 Aug 8.
2
A review of the pleiotropic actions of the IFN-inducible CXC chemokine receptor 3 ligands in the synovial microenvironment.CXCR3 配体在滑膜微环境中的多效作用综述。
Cell Mol Life Sci. 2023 Mar 2;80(3):78. doi: 10.1007/s00018-023-04715-w.
3
An Interleukin-4 and Interleukin-13 Induced Atopic Dermatitis Human Skin Equivalent Model by a Skin-On-A-Chip.一种基于皮肤芯片的白细胞介素-4 和白细胞介素-13 诱导的特应性皮炎人体皮肤等效模型。
Int J Mol Sci. 2022 Feb 14;23(4):2116. doi: 10.3390/ijms23042116.
4
Interleukin 17 Promotes Expression of Alarmins S100A8 and S100A9 During the Inflammatory Response of Keratinocytes.白细胞介素 17 在角质形成细胞的炎症反应中促进警报素 S100A8 和 S100A9 的表达。
Front Immunol. 2021 Feb 12;11:599947. doi: 10.3389/fimmu.2020.599947. eCollection 2020.
5
Delayed application of silver nanoparticles reveals the role of early inflammation in burn wound healing.延迟应用纳米银揭示了早期炎症在烧伤创面愈合中的作用。
Sci Rep. 2020 Apr 14;10(1):6338. doi: 10.1038/s41598-020-63464-z.
6
Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer.SOCS1 调节在自身免疫性疾病和癌症治疗中的治疗意义
Front Pharmacol. 2019 Apr 11;10:324. doi: 10.3389/fphar.2019.00324. eCollection 2019.
7
Chemokine CXCL10 and Coronavirus-Induced Neurologic Disease.趋化因子CXCL10与冠状病毒诱导的神经疾病
Viral Immunol. 2019 Jan/Feb;32(1):25-37. doi: 10.1089/vim.2018.0073. Epub 2018 Aug 15.
8
Predictive Biomarkers of Gastroesophageal Reflux Disease and Barrett's Esophagus in World Trade Center Exposed Firefighters: a 15 Year Longitudinal Study.世界贸易中心暴露消防员的胃食管反流病和巴雷特食管的预测生物标志物：一项长达 15 年的纵向研究。
Sci Rep. 2018 Feb 15;8(1):3106. doi: 10.1038/s41598-018-21334-9.
9
Psoriasis, Psoriatic Arthritis, and Thyroid Autoimmunity.银屑病、银屑病关节炎与甲状腺自身免疫性疾病
Front Endocrinol (Lausanne). 2017 Jun 19;8:139. doi: 10.3389/fendo.2017.00139. eCollection 2017.
10
Differential gene and protein expression of chemokines and cytokines in synovial fluid of patients with arthritis.关节炎患者滑液中趋化因子和细胞因子的基因与蛋白差异表达
Arthritis Res Ther. 2016 Dec 13;18(1):296. doi: 10.1186/s13075-016-1196-6.
本文引用的文献
1
Epidermal cell (keratinocyte)-derived thymocyte-activating factor (ETAF).表皮细胞（角质形成细胞）衍生的胸腺细胞激活因子（ETAF）。
J Immunol. 1981 Oct;127(4):1493-8.
2
Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed.人α-、β-和γ-肌动蛋白mRNA全长cDNA克隆的分离与鉴定：骨骼肌肌动蛋白而非细胞质肌动蛋白具有一个随后会被去除的氨基端半胱氨酸。
Mol Cell Biol. 1983 May;3(5):787-95. doi: 10.1128/mcb.3.5.787-795.1983.
3
Lectins as markers of human epidermal cell differentiation.凝集素作为人类表皮细胞分化的标志物。
Differentiation. 1982;22(3):205-10. doi: 10.1111/j.1432-0436.1982.tb01252.x.
4
Epidermal T lymphocytes and HLA-DR expression in psoriasis.银屑病中的表皮T淋巴细胞与HLA - DR表达
Br J Dermatol. 1984 May;110(5):555-64. doi: 10.1111/j.1365-2133.1984.tb04678.x.
5
Recombinant gamma interferon induces HLA-DR expression on cultured human keratinocytes.重组γ干扰素可诱导培养的人角质形成细胞表达HLA - DR。
J Invest Dermatol. 1984 Aug;83(2):88-90. doi: 10.1111/1523-1747.ep12262597.
6
The use of monoclonal antibody to keratin in human epidermal disease: alterations in immunohistochemical staining pattern.单克隆抗体在人类表皮疾病中对角蛋白的应用：免疫组织化学染色模式的改变
J Invest Dermatol. 1983 Sep;81(3):224-30. doi: 10.1111/1523-1747.ep12518198.
7
Clonal growth of human keratinocytes with small amounts of dialyzed serum.使用少量透析血清进行人角质形成细胞的克隆生长。
In Vitro. 1980 Jun;16(6):526-40. doi: 10.1007/BF02626466.
8
Preparation and characterization of monoclonal antibodies directed at epitopes of human IFN-gamma.
Hybridoma. 1984 Winter;3(4):321-32. doi: 10.1089/hyb.1984.3.321.
9
Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins.γ干扰素通过转录调控一个与血小板蛋白具有同源性的早期反应基因。
Nature. 1985;315(6021):672-6. doi: 10.1038/315672a0.
10
Biologic properties of epidermal cell thymocyte-activating factor (ETAF).表皮细胞胸腺细胞激活因子（ETAF）的生物学特性。
J Invest Dermatol. 1985 Jul;85(1 Suppl):176s-179s. doi: 10.1111/1523-1747.ep12276378.
Zotero 插件