Department of Dermatology, School of Medicine, University of California San Diego, La Jolla, California, USA.
Department of Dermatology, School of Medicine, University of California San Diego, La Jolla, California, USA.
J Invest Dermatol. 2024 Nov;144(11):2377-2398. doi: 10.1016/j.jid.2024.06.1280. Epub 2024 Aug 8.
The function of keratinocytes (KCs) to form a barrier and produce cytokines is well-known, but recent progress has revealed many different roles for KCs in regulation of skin immunity. In this review, we provide an update on the current understanding of how KCs communicate with microbes, immunocytes, neurons, and other cells to form an effective immune barrier. We catalog the large list of genes and metabolites of KCs that participate in host defense and discuss the mechanisms of immune crosstalk, addressing how KCs simultaneously form a physical barrier, communicate with fibroblasts, and control immune signals. Overall, the signals sent and received by KCs are an exciting group of therapeutic targets to explore in the treatment of dermatologic disorders.
角质形成细胞（KCs）形成屏障和产生细胞因子的功能是众所周知的，但最近的进展揭示了 KCs 在调节皮肤免疫方面的许多不同作用。在这篇综述中，我们提供了角质形成细胞如何与微生物、免疫细胞、神经元和其他细胞进行通信以形成有效的免疫屏障的最新认识。我们列出了角质形成细胞参与宿主防御的大量基因和代谢物，并讨论了免疫串扰的机制，探讨了角质形成细胞如何同时形成物理屏障、与成纤维细胞通信以及控制免疫信号。总的来说，角质形成细胞发出和接收的信号是一组令人兴奋的治疗靶点，可用于治疗皮肤疾病。
