伊曲康唑预防肺移植受者侵袭性曲霉感染
Itraconazole prophylaxis for invasive Aspergillus infection in lung transplantation.
作者信息
Kato K, Nagao M, Nakano S, Yunoki T, Hotta G, Yamamoto M, Matsumura Y, Ito Y, Takakura S, Chen F, Bando T, Matsuda Y, Matsubara K, Date H, Ichiyama S
机构信息
Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
出版信息
Transpl Infect Dis. 2014 Apr;16(2):340-3. doi: 10.1111/tid.12187. Epub 2014 Mar 5.
Invasive Aspergillus infection (IA) is a significant cause of morbidity in lung transplantation (LT). However, its optimal prophylaxis is unclear. We routinely administer itraconazole (ITCZ) prophylaxis to all patients undergoing LT. In this study, we retrospectively evaluated the duration of prophylaxis and risk factors of IA. Among 30 adult patients who underwent LT, 5 patients developed IA. All patients with IA stopped ITCZ treatment within 1 year. At least 1 year of ITCZ prophylaxis is essential for the prevention of IA. Cytomegalovirus infection, renal replacement therapy, and tracheotomy were risk factors for IA.
侵袭性曲霉感染（IA）是肺移植（LT）患者发病的重要原因。然而，其最佳预防方案尚不清楚。我们常规对所有接受LT的患者给予伊曲康唑（ITCZ）预防治疗。在本研究中，我们回顾性评估了预防治疗的持续时间及IA的危险因素。在30例接受LT的成年患者中，5例发生了IA。所有IA患者均在1年内停止了ITCZ治疗。至少1年的ITCZ预防治疗对预防IA至关重要。巨细胞病毒感染、肾脏替代治疗和气管切开术是IA的危险因素。
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