Lindqvist P G, Pettersson K, Morén A, Kublickas M, Nordström L
Department of Obstetrics and Gynaecology, Clintec, Karolinska Institute, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
BJOG. 2014 Aug;121(9):1108-15; discussion 1116. doi: 10.1111/1471-0528.12654. Epub 2014 Mar 5.
To study whether a routine with a routine ultrasound examination (routine scan) at 41 gestational weeks as compared with ultrasound on clinical indication (indicated scan), lowered the risk of severe adverse fetal outcome in post-term period.
A retrospective cohort study.
Karolinska University Hospital, Stockholm, Sweden.
Eight years of deliveries, 2002-2009.
One of the two delivery units at Karolinska University Hospital used a routine scan at 41 week of gestation and the other unit used an indicated scan. Severe adverse fetal outcome were defined: severe asphyxia, death or cerebral damage. The study was analysed using logistic regression with adjustment for potential confounders.
Differences in post-term severe adverse fetal outcome.
No increased risk of post-term severe adverse fetal outcome was seen at the unit using a routine scan; conversely, a 48% significantly increased risk was seen at the unit using an indicated scan (OR 0.89, 95% confidence interval, CI, 0.5-1.5 and OR 1.48, 95% CI 1.06-2.1, respectively). Comparing post-term periods, there was no significantly increased risk at the unit using indicated scans (OR 1.6, 95% CI 0.9-3.0). There was a 60% increased prevalence of small-for-gestational age (SGA) newborns in the post-term period at the unit using indicated scans (OR 1.6, 95% CI 1.1-2.4), but no differences in operative delivery.
A policy to use routine scans at 41 weeks of gestation seems to normalise an increased post-term risk of severe adverse fetal outcome, possible due to increased awareness of SGA and/or oligohydramniosis.
研究与根据临床指征进行超声检查(指征性扫描)相比,在妊娠41周进行常规超声检查(常规扫描)是否能降低过期妊娠时严重不良胎儿结局的风险。
一项回顾性队列研究。
瑞典斯德哥尔摩卡罗林斯卡大学医院。
2002年至2009年八年期间的分娩病例。
卡罗林斯卡大学医院的两个分娩单元之一在妊娠41周时采用常规扫描,另一个单元采用指征性扫描。严重不良胎儿结局定义为:严重窒息、死亡或脑损伤。采用逻辑回归分析该研究,并对潜在混杂因素进行校正。
过期妊娠时严重不良胎儿结局的差异。
采用常规扫描的单元未发现过期妊娠严重不良胎儿结局风险增加;相反,采用指征性扫描的单元出现了48%的显著风险增加(分别为OR 0.89,95%置信区间,CI,0.5 - 1.5和OR 1.48,95% CI 1.06 - 2.1)。比较过期妊娠阶段,采用指征性扫描的单元风险未显著增加(OR 1.6,95% CI 0.9 - 3.0)。在采用指征性扫描的单元,过期妊娠时小于胎龄儿(SGA)新生儿患病率增加了60%(OR 1.6,95% CI 1.1 - 2.4),但手术分娩方面无差异。
在妊娠41周进行常规扫描的策略似乎使过期妊娠时严重不良胎儿结局风险增加的情况正常化,可能是由于对SGA和/或羊水过少的认识提高。