Murzakanova Gulim, Räisänen Sari, Jacobsen Anne Flem, Yli Branka M, Tingleff Tiril, Laine Katariina
Department of Obstetrics, Oslo University Hospital, University of Oslo, Pb 4965, Nydalen, 0424, Oslo, Norway.
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Arch Gynecol Obstet. 2025 Apr;311(4):1007-1015. doi: 10.1007/s00404-024-07869-5. Epub 2024 Dec 17.
There is an ongoing discussion on whether the benefits of term elective labor induction outweigh its potential risks. This study evaluated the utility of a comprehensive clinical examination in identifying low-risk pregnancies suitable for expectant management beyond gestational age 40‒41 weeks and compared their outcomes with earlier labor induction by indication.
Pregnant women (n = 722) with ≥ 40 + 0 gestational weeks referred to a tertiary hospital were included in this prospective cohort. The study population was divided into the primary induction group (induction before 42 + 0 gestational weeks) and the expectant management group (spontaneous labor onset or induction at 42 + 0 gestational weeks), by decision based on a primary consultation. The Chi-square test and logistic regression were applied. The outcome measures were composite adverse fetal outcome (admission to a neonatal intensive care unit, metabolic acidosis, or Apgar score < 7 at 5 min), treatment with intrapartum antibiotics, intrapartum maternal fever ≥ 38 °C, intrapartum cesarean section, and postpartum hemorrhage ≥ 1500 ml.
The main outcome measures did not differ significantly between the primary induction group (n = 258) and the expectant management group (n = 464): composite adverse fetal outcome (OR = 2.29, 95% CI = 0.92-5.68; p = 0.07), intrapartum cesarean section (OR = 1.00, 95% CI = 0.64-1.56; p = 1.00), postpartum hemorrhage ≥ 1500 ml (OR = 1.89, 95% CI = 0.92-3.90; p = 0.09), intrapartum maternal fever ≥ 38 °C (OR = 1.26, 95% CI = 0.83-1.93; p = 0.28), or treatment with intrapartum antibiotics (OR = 1.25, 95% CI = 0.77-2.02; p = 0.37).
A comprehensive clinical examination at 40‒41 gestational weeks can identify pregnancies that might be managed expectantly until 42 gestational weeks obtaining similar outcomes to those induced earlier.
关于足月选择性引产的益处是否超过其潜在风险的讨论仍在继续。本研究评估了全面临床检查在识别适合孕40 - 41周后期待管理的低风险妊娠中的作用,并将其结局与按指征早期引产的结局进行比较。
本前瞻性队列研究纳入了转诊至一家三级医院、孕周≥40 + 0周的孕妇(n = 722)。根据初次会诊结果,将研究人群分为初次引产组(孕42 + 0周前引产)和期待管理组(自然发动分娩或孕42 + 0周时引产)。应用卡方检验和逻辑回归分析。结局指标包括复合不良胎儿结局(入住新生儿重症监护病房、代谢性酸中毒或5分钟时阿氏评分<7分)、产时使用抗生素治疗、产时产妇发热≥38℃、产时剖宫产以及产后出血≥1500 ml。
初次引产组(n = 258)和期待管理组(n = 464)之间的主要结局指标无显著差异:复合不良胎儿结局(比值比[OR]=2.29,95%置信区间[CI]=0.92 - 5.68;p = 0.07)、产时剖宫产(OR = 1.00,95% CI = 0.64 - 1.56;p = 1.00)、产后出血≥1500 ml(OR = 1.89,95% CI = 0.92 - 3.90;p = 0.09)、产时产妇发热≥38℃(OR = 1.26,95% CI = 0.83 - 1.93;p = 0.28)或产时使用抗生素治疗(OR = 1.25,95% CI = 0.77 - 2.02;p = 0.37)。
孕40 - 41周时进行的全面临床检查可识别出可能期待管理至孕42周的妊娠,其结局与早期引产相似。