Liang Jun, Wang Yu, Li Hongyan, Liu Xuekui, Qiu Qinqin, Qi Lu
Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, China.
Xuzhou Medical College, Xuzhou, Jiangsu, China.
PLoS One. 2014 Mar 3;9(3):e90101. doi: 10.1371/journal.pone.0090101. eCollection 2014.
Hepatic steatosis has been related to insulin resistance and increased diabetes risk. We assessed whether combination of diabetes risk factors, evaluated by the Finnish Diabetes Risk Score, was associated with risk of hepatic steatosis in an apparently healthy Chinese population.
The study samples were from a community-based health examination survey in central China. In total 1,780 men and women (18-64 y) were included in the final analyses. Hepatic steatosis was diagnosed by ultrasonography. We created combination of diabetes risk factors score on basis of age, Body Mass Index, waist circumference, physical activity at least 4 h a week, daily consumption of fruits, berries or vegetables, history of antihypertensive drug treatment, history of high blood glucose. The total risk score is a simple sum of the individual weights, and values range from 0 to 20.
Hepatic steatosis was present 18% in the total population. In multivariate models, the odds ratios of hepatic steatosis were 1.20 (95%CI 1.15-1.25) in men and 1.25 (95%CI 1.14-1.37) in women by each unit increase in the combination of diabetes risk factors score, after adjustment for blood pressure, liver enzymes, plasma lipids, and fasting glucose. The area under the receiver operating characteristic curve for hepatic steatosis was 0.78 (95%CI 0.76-0.80), 0.76 in men (95%CI 0.74-0.78) and 0.83 (95%CI 0.79-0.87) in women.
Our data suggest that combination of major diabetes risk factors was significantly related to risk of hepatic steatosis in Chinese adults.
肝脂肪变性与胰岛素抵抗及糖尿病风险增加有关。我们评估了通过芬兰糖尿病风险评分评估的糖尿病风险因素组合是否与明显健康的中国人群的肝脂肪变性风险相关。
研究样本来自中国中部一项基于社区的健康检查调查。最终分析纳入了1780名男性和女性（18 - 64岁）。通过超声检查诊断肝脂肪变性。我们根据年龄、体重指数、腰围、每周至少4小时的身体活动、每日水果、浆果或蔬菜的摄入量、抗高血压药物治疗史、高血糖病史创建了糖尿病风险因素组合评分。总风险评分是各个权重的简单相加，取值范围为0至20。
总体人群中肝脂肪变性的发生率为18%。在多变量模型中，在校正血压、肝酶、血脂和空腹血糖后，糖尿病风险因素组合评分每增加一个单位，男性肝脂肪变性的优势比为1.20（95%置信区间1.15 - 1.25），女性为1.25（95%置信区间1.14 - 1.37）。肝脂肪变性的受试者工作特征曲线下面积为0.78（95%置信区间0.76 - 0.80），男性为0.76（95%置信区间0.74 - 0.78），女性为0.83（95%置信区间0.79 - 0.87）。
我们的数据表明，主要糖尿病风险因素的组合与中国成年人的肝脂肪变性风险显著相关。
