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陕西省儿童基本药物的可及性:价格、供应情况、可负担性及价格构成调查

Access to paediatric essential medicines: a survey of prices, availability, affordability and price components in Shaanxi Province, China.

作者信息

Wang Xiao, Fang Yu, Yang Shimin, Jiang Minghuan, Yan Kangkang, Wu Lina, Lv Bing, Shen Qian

机构信息

Department of Pharmacy Administration, School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, China.

Department of Pharmacy Administration, School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, China; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, United States of America.

出版信息

PLoS One. 2014 Mar 3;9(3):e90365. doi: 10.1371/journal.pone.0090365. eCollection 2014.

Abstract

OBJECTIVE

To evaluate the prices and availability of paediatric essential medicines in Shaanxi Province, China.

METHODS

Price and availability data for 28 paediatric essential medicines were collected from 60 public hospitals and 60 retail pharmacies in six areas of Shaanxi Province using a standardised methodology developed by the World Health Organization and Health Action International, during November to December 2012. Affordability was measured as the number of days' wages required for the lowest-paid unskilled government worker to purchase standard treatments for common conditions. Data on medicine price components were collected from hospitals, wholesalers and distributors to obtain price mark-ups.

FINDINGS

The mean availabilities of originator brands (OBs) and lowest-priced generics (LPGs) were 10.8% and 27.3% in the public hospitals and 11.9% and 20.6% in the private pharmacies. The public procurement and retail prices were 2.25 and 2.59 times the international reference prices (IRPs) for three OBs, and 0.52 and 0.93 times for 20 LPGs. In the private sector, the final prices for OBs and LPGs were 3.89 and 1.25 times their IRPs. The final price in the private sector was 2.7% lower than in the public sector for OBs, and 14.1% higher for LPGs. Generally, standard treatments cost less than 1 day's wages in both sectors. Distribution mark-ups applied to brand salbutamol in Xi'an was 65.5%, and up to 185.3% for generic. Cumulative mark-ups for LPGs in Ankang were also high, from 33% to 50%. The manufacturer's selling price is the largest contributor to the final price in both areas.

CONCLUSIONS

The government should approve a list of national paediatric essential medicines. The availability, price and affordability of these should be improved in both public hospitals and private pharmacies to enable children to obtain effective treatment. Measures should be taken to improve the efficiency of the centralised medicine purchasing system.

摘要

目的

评估中国陕西省儿科基本药物的价格及可及性。

方法

2012年11月至12月期间,采用世界卫生组织和国际卫生行动组织制定的标准化方法,从陕西省六个地区的60家公立医院和60家零售药店收集了28种儿科基本药物的价格和可及性数据。可负担性通过支付最低薪酬的非技术政府工作人员购买常见疾病标准治疗药物所需的天数工资来衡量。从医院、批发商和经销商处收集药品价格构成数据,以获取价格加价情况。

研究结果

公立医院中原研品牌药(OBs)和最低价仿制药(LPGs)的平均可及率分别为10.8%和27.3%,私立药店中分别为11.9%和20.6%。三种原研品牌药的公共采购价格和零售价格分别是国际参考价格(IRPs)的2.25倍和2.59倍,20种最低价仿制药分别是0.52倍和0.93倍。在私营部门,原研品牌药和最低价仿制药的最终价格分别是其国际参考价格的3.89倍和1.25倍。私营部门中原研品牌药的最终价格比公共部门低2.7%,最低价仿制药则高14.1%。总体而言,两个部门的标准治疗费用均低于1天的工资。西安地区品牌沙丁胺醇的分销加价为65.5%,仿制药高达185.3%。安康地区最低价仿制药的累计加价也很高,从33%到50%。在这两个地区,制造商的销售价格在最终价格中占比最大。

结论

政府应批准一份国家儿科基本药物清单。应提高公立医院和私立药店中这些药物的可及性、价格和可负担性,以使儿童能够获得有效治疗。应采取措施提高集中药品采购系统的效率。

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