Darszon Alberto, Hernández-Cruz Arturo
Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM, Campus Cuernavaca), Avenida Universidad #2001, Col. Chamilpa, Cuernavaca, Morelos, CP 62210, Mexico,
Pflugers Arch. 2014 Apr;466(4):819-31. doi: 10.1007/s00424-014-1478-2. Epub 2014 Mar 6.
Cell function is importantly regulated by the intracellular concentration of Ca(2+) ([Ca(2+)]i). Sperm development and function are deeply influenced by [Ca(2+)]i which is modulated amongst other ion transporters by plasma membrane Ca(2+) permeable channels. The presence and role of voltage-dependent Ca(2+) channels (CaV) of the T-type (CaV3) in sperm physiology have become a matter of debate in recent years. Though they are functionally present in later stages of development in spermatogenic cells and testicular sperm and their mRNAs and proteins detected from spermatogenic cells to mature mammalian spermatozoa, their currents have not been recorded in mature spermatozoa. This review critically summarizes the evidence for the involvement of CaV3 channels in sperm development and function.
细胞功能受到细胞内钙离子浓度（[Ca(2+)]i）的重要调节。精子的发育和功能深受[Ca(2+)]i的影响，而[Ca(2+)]i在其他离子转运体中受质膜钙离子通透通道的调节。近年来，T型电压依赖性钙离子通道（CaV3）在精子生理学中的存在及其作用已成为一个有争议的问题。尽管它们在生精细胞和睾丸精子发育的后期阶段有功能表达，并且从生精细胞到成熟哺乳动物精子都能检测到它们的mRNA和蛋白质，但尚未在成熟精子中记录到它们的电流。这篇综述批判性地总结了CaV3通道参与精子发育和功能的证据。
