Liang Yujia, Deng Jun, Xiong Ying, Wang Songping, Xiong Wei
Department of Respiratory Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, Sichuan Province, People's Republic of China,
Tumour Biol. 2014 Jun;35(6):5613-8. doi: 10.1007/s13277-014-1742-2. Epub 2014 Mar 5.
The relationship between excision repair cross-complementing group 5 (ERCC5) rs17655 polymorphism and lung cancer risk remains controversial. To clarify the association, we conducted a comprehensive meta-analysis of all published case-control studies. PubMed, Web of Science, and CNKI were searched to identify the possibly eligible publications. Pooled odds ratio (OR) was estimated using the fixed effect model. Q test and I (2) index were used to evaluate heterogeneity between studies, and Egger's and Begg's tests were utilized to assess publication bias. Meta-analysis of nine case-control studies including 4,044 cases and 5,100 controls indicated that there was no global association between rs17655 polymorphism and lung cancer risk. Subgroup analyses according to ethnicity and histologic type revealed similar results. In summary, our meta-analysis suggests that ERCC5 rs17655 polymorphism may not contribute to genetic susceptibility for lung cancer.
切除修复交叉互补基因5（ERCC5）rs17655多态性与肺癌风险之间的关系仍存在争议。为了阐明这种关联，我们对所有已发表的病例对照研究进行了全面的荟萃分析。通过检索PubMed、Web of Science和中国知网来识别可能符合条件的出版物。采用固定效应模型估计合并比值比（OR）。使用Q检验和I²指数评估研究间的异质性，并采用Egger检验和Begg检验评估发表偏倚。对9项病例对照研究（包括4044例病例和5100例对照）的荟萃分析表明，rs17655多态性与肺癌风险之间不存在总体关联。根据种族和组织学类型进行的亚组分析得出了类似的结果。总之，我们的荟萃分析表明，ERCC5 rs17655多态性可能不会导致肺癌的遗传易感性。
