Na Nari, Dun Eer, Ren Lidong, Li Guoxin
Department of General Surgery, Nanfang Hospital, Southern Medical University Guangzhou, China ; Department of Thyroid, Breast, Hernia and Vascular Surgery, Inner Mongolia People's Hospital Hohhot, China.
Department of Respiratory, Inner Mongolia People's Hospital Hohhot, China.
Int J Clin Exp Pathol. 2015 Mar 1;8(3):3192-7. eCollection 2015.
We conducted a case-control study to evaluate the association between ERCC5 polymorphism and breast cancer risk. 325 breast cancer patients and 325 controls were recruited in our study between January 2011 and March 2014. ERCC5 rs1047768, rs2094258, rs2296147, rs751402 and rs873601 polymorphisms were genotyped, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. By logistic regression analysis, we found that individuals with AA genotype of rs2094258 was associated with increased risk of breast cancer when compared with wide-type genotype, and the OR (95% CI) was 1.80 (1.12-2.92) for AA genotype. Individuals with GA+GG genotype of rs2094258 were significantly correlated with increased risk of breast cancer in tobacco smokers, and the OR (95% CI) was 7.35 (1.21-47.20). In conclusion, our study indicated that ERCC5 rs2094258 polymorphism may contribute to the risk of breast cancer.
我们进行了一项病例对照研究，以评估ERCC5基因多态性与乳腺癌风险之间的关联。在2011年1月至2014年3月期间，我们的研究招募了325例乳腺癌患者和325名对照。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析法对ERCC5基因的rs1047768、rs2094258、rs2296147、rs751402和rs873601多态性进行基因分型。通过逻辑回归分析，我们发现，与野生型基因型相比，rs2094258基因AA基因型个体患乳腺癌的风险增加，AA基因型的比值比（95%可信区间）为1.80（1.12 - 2.92）。rs2094258基因GA + GG基因型个体在吸烟者中与患乳腺癌风险增加显著相关，比值比（95%可信区间）为7.35（1.21 - 47.20）。总之，我们的研究表明，ERCC5基因rs2094258多态性可能与乳腺癌风险有关。
