Bouquet F, Maillart E, Vignal C, Battistella M, Meignin V, Galicier L, Gout O
Department of Neurology, Fondation Ophtalmologique Rothschild, Paris, France
Department of Neurology, Fondation Ophtalmologique Rothschild, Paris, France.
Mult Scler. 2014 Jul;20(8):1140-2. doi: 10.1177/1352458514525000. Epub 2014 Mar 4.
Kikuchi-Fujimoto disease is a rare systemic disease with uncommon neurological involvement. We report the case of a 30-year-old Asian woman who presented a rapidly progressive loss of vision. Magnetic resonance imaging (MRI) of the optic nerve revealed an inflammation of the left optic nerve with chiasmatic involvement, without any encephalic or medullar lesion. Thoracic computed tomography scan showed bilateral axillary lymphadenopathy. Analysis of a biopsy of the axillary lymph node showed typical histological findings of Kikuchi-Fujimoto disease. There was no clinical or biological sign of associated systemic lupus erythematosus. The patient spontaneously recovered normal visual acuity in 4 weeks, with resolution of MRI abnormalities. No optic neuritis relapse or neurological event occurred in a 3-year follow-up. To our knowledge this is the first case of optic neuritis associated with Kikuchi-Fujimoto disease.
菊池-藤本病是一种罕见的全身性疾病，神经系统受累情况不常见。我们报告了一例30岁亚洲女性病例，该患者出现视力迅速减退。视神经磁共振成像（MRI）显示左侧视神经炎症累及视交叉，无脑或脊髓病变。胸部计算机断层扫描显示双侧腋窝淋巴结肿大。腋窝淋巴结活检分析显示菊池-藤本病的典型组织学表现。无相关系统性红斑狼疮的临床或生物学迹象。患者在4周内视力自发恢复正常，MRI异常消失。在3年的随访中未发生视神经炎复发或神经系统事件。据我们所知，这是首例与菊池-藤本病相关的视神经炎病例。
