Gallien S, Lagrange-Xelot M, Crabol Y, Brière J, Galicier L, Molina J-M
Service de maladies infectieuses et tropicales, hôpital Saint-Louis, 1, avenue Claude-de-Vellefaux, 75010 Paris, France.
Med Mal Infect. 2008 Jul;38(7):392-5. doi: 10.1016/j.medmal.2008.03.010. Epub 2008 Jun 18.
Kikuchi-Fujimoto's disease (KFD) or histiocytic narcotising lymphadenitis is a febrile benign lymphadenopathy of unknown etiology, involving more frequently cervical lymph nodes and diagnosed on biopsy of an affected node. It is sometimes associated with auto-immune diseases such as systemic lupus erythematosus (SLE). However less frequent symptoms including involvement of extracervical nodes, hepatosplenomegaly and systemic symptoms (weight loss, night sweats) are possible and suggest an infectious disease. We report the case of a Senegalese patient with positive Ag HBs who developed SLE and KFD mimicking tuberculosis. Atypical pseudo-infectious appearance of an inflammatory systemic disease is a rare occurrence and the diagnosis can be difficult.
菊池-藤本病(KFD)或组织细胞坏死性淋巴结炎是一种病因不明的发热性良性淋巴结病,更常累及颈部淋巴结,通过对受累淋巴结进行活检来诊断。它有时与自身免疫性疾病如系统性红斑狼疮(SLE)相关。然而,也可能出现较少见的症状,包括颈外淋巴结受累、肝脾肿大和全身症状(体重减轻、盗汗),提示为感染性疾病。我们报告一例乙肝表面抗原阳性的塞内加尔患者,该患者出现了类似结核病的系统性红斑狼疮和菊池-藤本病。炎症性全身性疾病的非典型假感染表现罕见,诊断可能困难。