Fuller Colin, Camilon Ryan, Nguyen Shaun, Jennings Jon, Day Terry, Gillespie M Boyd
Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.
Head Neck. 2015 May;37(5):755-62. doi: 10.1002/hed.23667. Epub 2014 May 5.
The purpose of this study was to critically review the published evidence concerning adjunctive diagnostic techniques in the diagnosis of oral lesions of unknown malignant potential.
We conducted a systematic literature review with meta-analysis using PubMed to search for articles published from June 1993 through June 2013 to identify prospective studies evaluating any diagnostic method, with tissue biopsy confirmation, in clinically evident oral lesions of unknown malignant potential. Aggregate weighted totals and SEs for true, false-positive, false-negative, and inadequate results were calculated and compared among subgroups.
Forty-eight articles satisfying inclusion criteria were identified. Twenty-five were included in quantitative synthesis.
Oral cytology holds higher diagnostic value than specialist's oral examination, which holds higher value than in vivo toluidine blue staining. This study does not support the use of computer-aided or liquid-based cytology. Future studies should be designed to test multiple methods in the same patient population to allow direct comparison among various techniques.
本研究旨在严格审查已发表的关于辅助诊断技术在诊断恶性潜能未知的口腔病变中的证据。
我们使用PubMed进行了一项系统的文献综述和荟萃分析，以检索1993年6月至2013年6月发表的文章，以确定在经组织活检证实的临床上明显的恶性潜能未知的口腔病变中评估任何诊断方法的前瞻性研究。计算并比较了各亚组中真阳性、假阳性、假阴性和结果不充分的汇总加权总数及标准误。
确定了48篇符合纳入标准的文章。25篇纳入定量综合分析。
口腔细胞学的诊断价值高于专科医生的口腔检查，而专科医生的口腔检查又高于活体甲苯胺蓝染色。本研究不支持使用计算机辅助或液基细胞学检查。未来的研究应设计为在同一患者群体中测试多种方法，以便对各种技术进行直接比较。
