Kanas R J, Abrams A M, Recher L, Jensen J L, Handlers J P, Wuerker R B
Veterans Administration Medical Center, Long Beach, Los Angeles, Calif.
Oral Surg Oral Med Oral Pathol. 1988 Sep;66(3):334-40. doi: 10.1016/0030-4220(88)90241-1.
We compared the light microscopic features and immunoperoxidase staining for human papillomavirus antigen of oral hairy leukoplakia (OHL) and flat condylomatous lesions of the cervix. Our findings support the conclusion that OHL and flat condylomatous lesions of the cervix are not similar morphologically or etiologically. Therefore the term koilocyte seems inappropriate to describe the swollen epithelial cells in OHL. The various diagnostic criteria for a diagnosis of OHL were reviewed. On the basis of the review of our cases of OHL and our review of the literature, we conclude that a definitive diagnosis of OHL requires either the biochemical evidence of Epstein-Barr virus or the ultrastructural demonstration of herpesviruses in suspected lesions.
我们比较了口腔毛状白斑（OHL）与人乳头瘤病毒抗原的光镜特征及免疫过氧化物酶染色，以及宫颈扁平湿疣病变。我们的研究结果支持以下结论：OHL与宫颈扁平湿疣病变在形态学或病因学上并不相似。因此，用“空泡细胞”这一术语来描述OHL中肿胀的上皮细胞似乎并不恰当。我们回顾了OHL的各种诊断标准。基于对我们的OHL病例及文献的回顾，我们得出结论，OHL的确切诊断需要在疑似病变中找到爱泼斯坦-巴尔病毒的生化证据或疱疹病毒的超微结构证据。
