Sciubba J, Brandsma J, Schwartz M, Barrezueta N
Department of Dentistry, Long Island Jewish Medical Center, New Hyde Park, NY 11042.
Oral Surg Oral Med Oral Pathol. 1989 Apr;67(4):404-10. doi: 10.1016/0030-4220(89)90382-4.
Hairy leukoplakia has been defined and confirmed as a specific oral mucosal marker for human immunodeficiency virus infection. Light microscopic findings include alteration of spinous layer cells, which contain nuclear chromatin abnormalities. Enlargement of spinous cells with ballooning degeneration is also characteristic. Ultrastructural morphology has defined the presence of large numbers of herpes-type virus particles within the intranuclear, cytoplasmic, and intercellular regions. Morphologically, the criteria of Epstein-Barr virus are satisfied. Southern blot analysis has confirmed the virus to be Epstein-Barr virus. Further hybridization analyses failed to show any evidence of human immunodeficiency virus or human papillomavirus in the lesions themselves. We conclude that hairy leukoplakia may represent an epithelial opportunistic Epstein-Barr virus infection. Finally, the production and shedding of Epstein-Barr virions into the oral cavity from the sites of hairy leukoplakia can occur separate from the usual tonsillar and oropharyngeal sites.
毛状白斑已被定义并确认为人类免疫缺陷病毒感染的一种特定口腔黏膜标志物。光镜检查结果包括棘层细胞改变，其细胞核染色质异常。棘细胞肿大并伴有气球样变性也是其特征。超微结构形态学已确定在核内、胞质内和细胞间区域存在大量疱疹型病毒颗粒。从形态学上看，符合爱泼斯坦 - 巴尔病毒的标准。Southern印迹分析已证实该病毒为爱泼斯坦 - 巴尔病毒。进一步的杂交分析未能在病变本身中显示出任何人类免疫缺陷病毒或人乳头瘤病毒的证据。我们得出结论，毛状白斑可能代表一种上皮性机会性爱泼斯坦 - 巴尔病毒感染。最后，爱泼斯坦 - 巴尔病毒颗粒从毛状白斑部位产生并脱落至口腔，这一过程可能独立于通常的扁桃体和口咽部部位发生。
