Siddiqui Anwar Hasan, Gulati Rajiv, Tauheed Nazia, Pervez Anjum
Senior Resident, Department of Physiology, JNMC, AMU , Aligarh, UP., India .
Professor, Department of Anesthesia, Jawaharlal Nehru Medical College , Aligarh Muslim University, Aligarh, UP, India .
J Clin Diagn Res. 2014 Jan;8(1):4-7. doi: 10.7860/JCDR/2014/6446.3912. Epub 2014 Jan 12.
Obesity is associated with increased oxidative stress and lipid peroxidation is thought to play a crucial role in the generation of atherosclerotic lesions of Acute Myocardial Infarction (AMI).
The case-control study contained 120 subjects divided in two groups, 60 patients with AMI and equal number of age- and sex-matched healthy subjects as controls. Ratio of Waist Circumference (WC) to Hip Circumference (HC) (waist-to-hip ratio) of all the subjects was recorded. Antioxidant status of the individuals was determined by measuring the serum levels of Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD). Estimation of Malondialdehyde (MDA), a marker of lipid peroxidation was used as a surrogate marker of free radical activity.
WHR was found to be significantly higher in patients of AMI as compared to controls. MDA levels were significantly high and antioxidants molecules GPx and SOD were significantly decreased in AMI patients as compared with control (p<0.001). WHR correlated positively to serum level of MDA and inversely to the serum level of antioxidant enzymes.
High Waist-to-hip ratio is associated with high concentrations of malondialdehyde level and low concentration of antioxidant's enzyme. This results in increased oxidative stress, a major causative factor of AMI.
肥胖与氧化应激增加有关，脂质过氧化被认为在急性心肌梗死（AMI）动脉粥样硬化病变的发生中起关键作用。
这项病例对照研究纳入了120名受试者，分为两组，60例AMI患者以及数量相等的年龄和性别匹配的健康受试者作为对照。记录所有受试者的腰围（WC）与臀围（HC）之比（腰臀比）。通过测量血清谷胱甘肽过氧化物酶（GPx）和超氧化物歧化酶（SOD）水平来确定个体的抗氧化状态。使用脂质过氧化标志物丙二醛（MDA）的测定作为自由基活性的替代标志物。
发现AMI患者的腰臀比显著高于对照组。与对照组相比，AMI患者的MDA水平显著升高，抗氧化分子GPx和SOD显著降低（p<0.001）。腰臀比与血清MDA水平呈正相关，与抗氧化酶血清水平呈负相关。
高腰臀比与高浓度丙二醛水平和低浓度抗氧化酶相关。这导致氧化应激增加，而氧化应激是AMI的主要致病因素。
