State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, China.
Org Lett. 2014 Mar 21;16(6):1768-71. doi: 10.1021/ol500469a. Epub 2014 Mar 6.
The trifluoromethyl-substituted anilines are biologically active compounds and useful building blocks. In this communication, we have developed the first visible-light-induced radical trifluoromethylation of free anilines with the commercially available and easily handled Togni reagent at room temperature. The resulting products were successfully transformed into a variety of valuable fluorine-containing molecules and heterocyclic compounds. This protocol provides an economical and powerful route to trifluoromethylated free anilines.
三氟甲基取代的苯胺是具有生物活性的化合物，也是有用的构建模块。在本通讯中，我们开发了首例在室温下使用市售且易于操作的 Togni 试剂实现游离苯胺的可见光诱导自由基三氟甲基化反应。所得产物可成功转化为多种有价值的含氟分子和杂环化合物。该方法为三氟甲基化游离苯胺提供了一种经济且强大的途径。
