通过光氧化还原催化实现室温下 α,β-不饱和羧酸的脱羧三氟甲基化反应。
Room temperature decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids by photoredox catalysis.
机构信息
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China.
出版信息
Chem Commun (Camb). 2014 Mar 4;50(18):2308-10. doi: 10.1039/c3cc48598f. Epub 2014 Jan 21.
PMID:24445904
Abstract
A visible-light-induced decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids, which uses the Togni reagent as the CF3 source is disclosed. The corresponding trifluoromethylated alkenes were obtained in moderate to high yields with excellent functional group tolerance at ambient temperature. Preliminary mechanistic analyses suggest a radical-type mechanism.
摘要
可见光诱导的α,β-不饱和羧酸的脱羧三氟甲基化反应被揭示，该反应使用 Togni 试剂作为 CF3 源。在室温下，具有良好官能团耐受性的相应的三氟甲基化烯烃以中等至高产率得到。初步的机理分析表明该反应可能为自由基型机理。
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