Pauli S L, Kokko M L, Suhonen R, Reunala T
Department of Dermatology, Central Hospital of Tampere, Finland.
Acta Derm Venereol. 1988;68(4):351-5.
We present 5 young men who developed acne fulminans. During the acute, febrile illness, all had musculoskeletal symptoms, and X-ray and bone scan examinations revealed that 4 of the patients had osteolytic bone lesions. The disease was resistant to various antibiotics and one patient needed surgical trepanation of the sternum. No evidence of sepsis or bacterial osteomyelitis was found, as all bacteriological cultures proved negative and the tissue reaction was unspecific. The dermatopathogenetic origin of bone lesions in the present patients seems evident, but speculation that the etiology depends on immune mechanisms remains open.
我们报告了5例暴发性痤疮的年轻男性患者。在急性发热性疾病期间，所有患者均有肌肉骨骼症状，X线和骨扫描检查显示4例患者有溶骨性骨病变。该疾病对多种抗生素耐药，1例患者需要进行胸骨环钻术。由于所有细菌培养均为阴性且组织反应无特异性，未发现败血症或细菌性骨髓炎的证据。目前患者骨病变的皮肤发病机制似乎很明显，但病因取决于免疫机制的推测仍未明确。
