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主动脉根部手术:对于这些患者,我们应该选择保留瓣膜的根部重建术还是复合人工血管瓣膜置换术仍是治疗的首选?

Surgery of the aortic root: should we go for the valve-sparing root reconstruction or the composite graft-valve replacement is still the first choice of treatment for these patients?

作者信息

Lamana Fernando de Azevedo, Dias Ricardo Ribeiro, Duncan Jose Augusto, Faria Leandro Batisti de, Malbouisson Luiz Marcelo Sa, Borges Luciano de Figueiredo, Mady Charles, Jatene Fábio Biscegli

机构信息

Universidade Federal de Minas Gerais, Belo Horizonte, MG, BR.

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, BR.

出版信息

Rev Bras Cir Cardiovasc. 2015 Jul-Sep;30(3):343-52. doi: 10.5935/1678-9741.20150028.

Abstract

OBJECTIVE

To compare the results of the root reconstruction with the aortic valve-sparing operation versus composite graft-valve replacement.

METHODS

From January 2002 to October 2013, 324 patients underwent aortic root reconstruction. They were 263 composite graft-valve replacement and 61 aortic valve-sparing operation (43 reimplantation and 18 remodeling). Twenty-six percent of the patients were NYHA functional class III and IV; 9.6% had Marfan syndrome, and 12% had bicuspid aortic valve. There was a predominance of aneurysms over dissections (81% vs. 19%), with 7% being acute dissections. The complete follow-up of 100% of the patients was performed with median follow-up time of 902 days for patients undergoing composite graft-valve replacement and 1492 for those undergoing aortic valve-sparing operation.

RESULTS

In-hospital mortality was 6.7% and 4.9%, respectively for composite graft-valve replacement and aortic valve-sparing operation (ns). During the late follow-up period, there was 0% moderate and 15.4% severe aortic regurgitation, and NYHA functional class I and II were 89.4% and 94%, respectively for composite graft-valve replacement and aortic valve-sparing operation (ns). Root reconstruction with aortic valve-sparing operation showed lower late mortality (P=0.001) and lower bleeding complications (P=0.006). There was no difference for thromboembolism, endocarditis, and need of reoperation.

CONCLUSION

The aortic root reconstruction with preservation of the valve should be the operation being performed for presenting lower late mortality and survival free of bleeding events.

摘要

目的

比较保留主动脉瓣手术与复合移植瓣膜置换术进行主动脉根部重建的结果。

方法

2002年1月至2013年10月,324例患者接受了主动脉根部重建手术。其中263例行复合移植瓣膜置换术,61例行保留主动脉瓣手术(43例再植入术和18例重塑术)。26%的患者为纽约心脏协会(NYHA)心功能Ⅲ级和Ⅳ级;9.6%患有马凡综合征,12%患有二叶式主动脉瓣。动脉瘤患者多于夹层患者(81%对19%),其中7%为急性夹层。对所有患者进行了100%的完整随访,接受复合移植瓣膜置换术患者的中位随访时间为902天,接受保留主动脉瓣手术患者的中位随访时间为1492天。

结果

复合移植瓣膜置换术和保留主动脉瓣手术的住院死亡率分别为6.7%和4.9%(无统计学差异)。在后期随访期间,复合移植瓣膜置换术和保留主动脉瓣手术的中度主动脉瓣反流发生率分别为0%和重度主动脉瓣反流发生率分别为15.4%,NYHA心功能Ⅰ级和Ⅱ级的患者分别为89.4%和94%(无统计学差异)。保留主动脉瓣手术进行主动脉根部重建显示出较低的后期死亡率(P=0.001)和较低的出血并发症发生率(P=0.006)。在血栓栓塞、心内膜炎和再次手术需求方面无差异。

结论

保留瓣膜的主动脉根部重建手术应作为一种能降低后期死亡率和无出血事件生存率的手术方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c7/4541781/49b64029711e/rbccv-30-03-0343-g01.jpg

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