呋喃妥因免疫介导的药物性肝损伤：一种常用药物的严重并发症。
Nitrofurantoin immune-mediated drug-induced liver injury: a serious complication of a commonly prescribed medication.
作者信息
Hydes Theresa, Wright Mark, Jaynes Eleanor, Nash Kathryn
机构信息
Department of Hepatology, University Hospital Southampton, Southampton, UK.
出版信息
BMJ Case Rep. 2014 Mar 5;2014:bcr2013203136. doi: 10.1136/bcr-2013-203136.
Abstract
Nitrofurantoin is recommended for first line prophylaxis of recurrent urinary tract infections. Despite a number of side effects it is increasingly prescribed due to its high efficacy, low cost and minimal antimicrobial resistance. Nitrofurantoin-induced immune-mediated liver injury is a particularly serious complication, resulting in both acute hepatic failure and cirrhosis with continued use. We describe the course of two patients who recently presented to our hospital in order to highlight this.
摘要
呋喃妥因被推荐用于复发性尿路感染的一线预防。尽管有一些副作用，但由于其高效、低成本和最小的抗菌耐药性，它的处方量越来越大。呋喃妥因引起的免疫介导性肝损伤是一种特别严重的并发症，持续使用会导致急性肝衰竭和肝硬化。我们描述了最近到我院就诊的两名患者的病程，以突出这一点。
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