Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Pathobiology, Division of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Front Cell Infect Microbiol. 2023 Jul 27;13:1148603. doi: 10.3389/fcimb.2023.1148603. eCollection 2023.
Nitrofurantoin (NF), a wide-spectrum antibiotic accessible since 1953, is utilized widely to treat urinary tract infections as it usually stays active against drug-resistant uropathogen. The use of Nitrofurantoin has increased exponentially since new guidelines have repositioned it as first-line therapy for uncomplicated lower urinary tract infection (UTI). To, although fluoroquinolones are usually used to re-evaluate the first- and second-line therapies for treating uncomplicated UTI, their level of utilization is thought to be inappropriately excessive and will eventually have a detrimental impact; thus, we hypothesize that NF might be the best choice for this condition, because of its low frequency of utilization and its high susceptibility in common UTI pathogens. It can be concluded from this review that NF can be considered as the most effective drug in the treatment of acute urinary infection, but due to the long-term side effects of this drug, especially in elderly patients, it is essential to introduce some criteria for prescribing NF in cases of chronic UTI.
呋喃妥因（NF）是一种广谱抗生素，自 1953 年以来广泛应用于治疗尿路感染，因为它通常对耐药尿路病原体保持活性。自新指南将其重新定位为治疗单纯性下尿路感染（UTI）的一线治疗药物以来，呋喃妥因的使用呈指数级增长。尽管氟喹诺酮类药物通常用于重新评估治疗单纯性 UTI 的一线和二线治疗药物，但它们的使用水平被认为过高，最终会产生不利影响；因此，我们假设 NF 可能是这种情况的最佳选择，因为它的使用率低，而且对常见的 UTI 病原体具有高度敏感性。从本次综述可以得出结论，NF 可被视为治疗急性尿路感染最有效的药物，但由于该药物存在长期副作用，特别是在老年患者中，因此在慢性 UTI 情况下开具 NF 处方时，必须引入一些标准。
