Li Jing, Wu Song, Wang Ming-Rui, Wang Ting-Ting, Li Bai-Kun, Zhu Ji-Min
Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230038, Anhui, China.
Rheumatol Int. 2014 Oct;34(10):1339-44. doi: 10.1007/s00296-014-2975-5. Epub 2014 Mar 6.
Nucleotide-binding oligomerization domain 2 (NOD2) is one of the most prominent member of the NOD-like receptors protein family that functions as intracellular pattern recognition receptors. Numerous studies have suggested the importance of NOD2 in defensing against microbial infections, regulation of the inflammatory process. It is shown that NOD2 contributes to the pathogenesis of various autoimmune and chronic inflammatory diseases, such as Crohn's disease, rheumatoid arthritis. The aim of this study is to summarize our current understandings of NOD2 function and the role of NOD2 in systemic lupus erythematosus (SLE). The following databases were searched: Pubmed, EMBASE and Web of Science for English-language sources, using the terms "lupus," "systemic lupus erythematosus," ''SLE," "immunity," "inflammatory" and "NOD2." Emerging data evidences that NOD2 has important biological effects in autoimmunity and inflammatory and might take part in the pathogenesis of SLE. Studies exploring the relationship between NOD2 and SLE are very limited. Whether NOD2 could be a potentially valuable therapeutic target for treatment for SLE, more understanding of the mechanism of NOD2 is needed in the future in SLE.
核苷酸结合寡聚化结构域2（NOD2）是NOD样受体蛋白家族中最突出的成员之一，作为细胞内模式识别受体发挥作用。大量研究表明NOD2在抵御微生物感染、调节炎症过程中具有重要作用。研究表明，NOD2参与了多种自身免疫性疾病和慢性炎症性疾病的发病机制，如克罗恩病、类风湿关节炎。本研究的目的是总结我们目前对NOD2功能以及NOD2在系统性红斑狼疮（SLE）中作用的认识。我们检索了以下数据库：用于英文文献来源的PubMed、EMBASE和科学网，检索词为“狼疮”“系统性红斑狼疮”“SLE”“免疫”“炎症”和“NOD2”。新出现的数据表明，NOD2在自身免疫和炎症中具有重要的生物学效应，可能参与SLE的发病机制。探索NOD2与SLE之间关系的研究非常有限。NOD2是否可能成为治疗SLE的潜在有价值的治疗靶点，未来在SLE中还需要对NOD2的机制有更多了解。
