Mazoujian G, Margolis R
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Am J Dermatopathol. 1988 Feb;10(1):28-35. doi: 10.1097/00000372-198802000-00004.
Sixty-five cases of benign sweat gland tumors of the skin were studied for the expression and localization of gross cystic disease fluid protein-15 (GCDFP-15) by immunoperoxidase methods. There was positive staining of tumors of probable apocrine differentiation in 10 of 11 cases of apocrine hidrocystoma and five of five cases of hidradenoma papilliferum. There was no immunoreactivity for GCDFP-15 for tumors of probable eccrine differentiation, including five cases of eccrine hidrocystoma, five cases of eccrine poroma, five cases of eccrine spiradenoma, 10 cases of clear cell hidradenoma, and nine cases of syringoma. There was variable positive staining of tumors of more uncertain histogenesis, including eight of eight cases of syringocystadenoma papilliferum, one of four cases of cylindroma, and two of two cases of chondroid syringoma (mixed tumor). The above data support a functional differentiation of the expression of GCDFP-15 by eccrine compared to apocrine glandular epithelium with benign tumor development.
采用免疫过氧化物酶法对65例皮肤良性汗腺肿瘤进行大体囊肿病液体蛋白-15（GCDFP-15）表达及定位研究。11例大汗腺囊瘤中的10例以及5例乳头状汗腺瘤中的5例可能具有大汗腺分化的肿瘤呈阳性染色。对于可能具有小汗腺分化的肿瘤，GCDFP-15无免疫反应性，包括5例小汗腺囊瘤、5例小汗腺汗孔瘤、5例小汗腺螺旋腺瘤、10例透明细胞汗腺瘤和9例汗管瘤。对于组织发生更不确定的肿瘤，有不同程度的阳性染色，包括8例乳头状汗管囊腺瘤中的8例、4例圆柱瘤中的1例以及2例软骨样汗管瘤（混合瘤）中的2例。上述数据支持与大汗腺腺上皮相比，小汗腺腺上皮在良性肿瘤发生过程中GCDFP-15表达的功能分化。
