Yates Joseph R, Mines Michael J, Subramanian Prem S, Rivera-Michlig Roxana, Cummings Thomas J, Eberhart Charles G
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ophthalmology Service, Madigan Army Medical Center, Tacoma, Washington, USA.
Ocul Oncol Pathol. 2019 Feb;5(2):94-101. doi: 10.1159/000490250. Epub 2018 Jul 5.
Cutaneous histiocytoid carcinoma can occur as a primary tumor of the periocular region. Morphologically similar histiocytoid carcinomas arising as primary tumors of the breast have a predilection for orbital metastases. They can occasionally contain regions with prominent vacuolated cytoplasm and minimal nuclear atypia, which mimic benign histiocytic lesions. Differentiating nonneoplastic, primary neoplastic, and metastatic histiocytoid lesions involving the periorbita can be challenging for both the clinician and the pathologist, and this distinction has management implications. Herein, we present 3 cases to illustrate the challenges of diagnosing periocular histiocytoid carcinoma.
皮肤组织细胞样癌可作为眼周区域的原发性肿瘤发生。形态学上类似的组织细胞样癌作为乳腺原发性肿瘤易发生眼眶转移。它们偶尔可含有细胞质空泡化明显且核异型性极小的区域，酷似良性组织细胞病变。区分累及眶周的非肿瘤性、原发性肿瘤性和转移性组织细胞样病变对临床医生和病理学家来说都具有挑战性，而这种区分具有管理意义。在此，我们展示3例病例以说明诊断眼周组织细胞样癌的挑战。
