The International ImMunoGenetics Information System® (IMGT®), Laboratoire d'ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine, UPR CNRS, Université Montpellier 2 , Montpellier , France.
Front Immunol. 2014 Feb 5;5:22. doi: 10.3389/fimmu.2014.00022. eCollection 2014.
IMGT(®), the international ImMunoGeneTics information system(®) (1), (CNRS and Université Montpellier 2) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989, IMGT(®) marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT(®) is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH), and proteins of the IgSF and MhSF superfamilies. IMGT(®) has been built on the IMGT-ONTOLOGY axioms and concepts, which bridged the gap between genes, sequences, and three-dimensional (3D) structures. The concepts include the IMGT(®) standardized keywords (concepts of identification), IMGT(®) standardized labels (concepts of description), IMGT(®) standardized nomenclature (concepts of classification), IMGT unique numbering, and IMGT Colliers de Perles (concepts of numerotation). IMGT(®) comprises seven databases, 15,000 pages of web resources, and 17 tools, and provides a high-quality and integrated system for the analysis of the genomic and expressed IG and TR repertoire of the adaptive immune responses. Tools and databases are used in basic, veterinary, and medical research, in clinical applications (mutation analysis in leukemia and lymphoma) and in antibody engineering and humanization. They include, for example IMGT/V-QUEST and IMGT/JunctionAnalysis for nucleotide sequence analysis and their high-throughput version IMGT/HighV-QUEST for next-generation sequencing (500,000 sequences per batch), IMGT/DomainGapAlign for amino acid sequence analysis of IG and TR variable and constant domains and of MH groove domains, IMGT/3Dstructure-DB for 3D structures, contact analysis and paratope/epitope interactions of IG/antigen and TR/peptide-MH complexes and IMGT/mAb-DB interface for therapeutic antibodies and fusion proteins for immune applications (FPIA).
IMGT(®)，国际免疫遗传学信息系统(®)(1)，(法国国家科学研究中心和蒙彼利埃大学 2 分校)是免疫遗传学和免疫信息学的全球参考。通过 1989 年的创建，IMGT(®)标志着免疫信息学的出现，它出现在免疫遗传学和生物信息学的接口处。IMGT(®)专门研究免疫球蛋白(IG)或抗体、T 细胞受体(TR)、主要组织相容性(MH)以及 IgSF 和 MhSF 超家族的蛋白质。IMGT(®)是基于 IMGT-ONTOLOGY 公理和概念构建的，这些公理和概念弥合了基因、序列和三维(3D)结构之间的差距。这些概念包括 IMGT(®)标准化关键字(识别概念)、IMGT(®)标准化标签(描述概念)、IMGT(®)标准化命名法(分类概念)、IMGT 唯一编号和 IMGT 珠饰(编号概念)。IMGT(®)包含七个数据库、15000 页网络资源和 17 个工具，为分析适应性免疫反应的基因组和表达 IG 和 TR 库提供了高质量和集成的系统。工具和数据库用于基础、兽医和医学研究、临床应用(白血病和淋巴瘤中的突变分析)以及抗体工程和人源化。例如，IMGT/V-QUEST 和 IMGT/JunctionAnalysis 用于核苷酸序列分析及其高通量版本 IMGT/HighV-QUEST 用于下一代测序(每次批量 50 万条序列)、IMGT/DomainGapAlign 用于 IG 和 TR 可变和恒定结构域以及 MH 凹槽结构域的氨基酸序列分析、IMGT/3Dstructure-DB 用于 3D 结构、IG/抗原和 TR/肽-MH 复合物的接触分析和表位/抗原相互作用以及 IMGT/mAb-DB 界面用于免疫应用的治疗性抗体和融合蛋白(FPIA)。
