Igout A, Scippo M L, Frankenne F, Hennen G
Endocrinologie Clinique et Expérimentale, Centre Hospitalier Universitaire, Liège.
Arch Int Physiol Biochim. 1988 Mar;96(1):63-7. doi: 10.3109/13813458809079626.
We have previously demonstrated the presence in human placenta and maternal serum of a GH variant, called human placental growth hormone (hPGH). We have also shown that the hGH-V gene is expressed at the placental level thus possibly coding for hPGH. The hGH-V cDNA has now been isolated from a lambda gt 11 human placenta cDNA library. Its sequence has been determined which firmly establishes the GH-V gene mode of splicing as well as the GH-V protein structure. Our data give final evidence of placental hGH-V gene expression and reinforce the hypothesis of identity between the hGH-V protein and hPGH.
