胎盘人生长激素作为生长激素-V基因表达产物的鉴定。

Identification of placental human growth hormone as the growth hormone-V gene expression product.

作者信息

Frankenne F, Scippo M L, Van Beeumen J, Igout A, Hennen G

机构信息

Experimental and Clinical Endocrinology, CHU B-23, Liege, Belgium.

出版信息

J Clin Endocrinol Metab. 1990 Jul;71(1):15-8. doi: 10.1210/jcem-71-1-15.

DOI:10.1210/jcem-71-1-15

PMID:2196278

Abstract

A GH variant of placental origin, placental GH, has recently been shown to replace pituitary GH in maternal serum during pregnancy. Besides, the GH variant (GH-V) gene has been demonstrated to be expressed in the placenta. The similarities between their known properties strongly suggest that the placental GH and the GH-V protein are the same molecular species. Here we provide final evidence that this is indeed the case by sequence analysis of both the 22K and 25K forms. Furthermore, the 25K form is shown to be glycosylated, while the 22K form is not. Both size variants of placental GH are, thus, likely to reflect the partial glycosylation of a unique peptidic chain.

摘要

一种源自胎盘的生长激素变体，即胎盘生长激素，最近已被证明在孕期可取代母体血清中的垂体生长激素。此外，已证实生长激素变体（GH-V）基因在胎盘中表达。它们已知特性之间的相似性有力地表明，胎盘生长激素和GH-V蛋白是同一分子种类。在此，我们通过对22K和25K两种形式进行序列分析，提供了这确实如此的最终证据。此外，25K形式显示为糖基化的，而22K形式则不是。因此，胎盘生长激素的这两种大小变体可能反映了一条独特肽链的部分糖基化情况。