系统生物学揭示了干扰素对呼吸道病毒感染的反应。
Systems biology unravels interferon responses to respiratory virus infections.
作者信息
Kroeker Andrea L, Coombs Kevin M
机构信息
Andrea L Kroeker, Department of Physiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
出版信息
World J Biol Chem. 2014 Feb 26;5(1):12-25. doi: 10.4331/wjbc.v5.i1.12.
Abstract
Interferon production is an important defence against viral replication and its activation is an attractive therapeutic target. However, it has long been known that viruses perpetually evolve a multitude of strategies to evade these host immune responses. In recent years there has been an explosion of information on virus-induced alterations of the host immune response that have resulted from data-rich omics technologies. Unravelling how these systems interact and determining the overall outcome of the host response to viral infection will play an important role in future treatment and vaccine development. In this review we focus primarily on the interferon pathway and its regulation as well as mechanisms by which respiratory RNA viruses interfere with its signalling capacity.
摘要
干扰素的产生是抵御病毒复制的重要防御机制，其激活是一个有吸引力的治疗靶点。然而，长期以来人们都知道病毒会不断进化出多种策略来逃避这些宿主免疫反应。近年来，由于数据丰富的组学技术，关于病毒诱导的宿主免疫反应改变的信息呈爆炸式增长。弄清楚这些系统如何相互作用以及确定宿主对病毒感染反应的总体结果，将在未来的治疗和疫苗开发中发挥重要作用。在这篇综述中，我们主要关注干扰素途径及其调节，以及呼吸道RNA病毒干扰其信号传导能力的机制。
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