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本文引用的文献

1
Targeting ribonucleotide reductase for cancer therapy.针对核糖核苷酸还原酶的癌症疗法。
Expert Opin Ther Targets. 2013 Dec;17(12):1423-37. doi: 10.1517/14728222.2013.840293. Epub 2013 Oct 1.
2
Intracellular deoxyribonucleotide pool imbalance and DNA damage in cells treated with hydroxyurea, an inhibitor of ribonucleotide reductase.细胞内脱氧核苷酸池失衡和 DNA 损伤在细胞用羟基脲处理时，一种核糖核苷酸还原酶抑制剂。
Mutagenesis. 2013 Nov;28(6):653-60. doi: 10.1093/mutage/get044. Epub 2013 Sep 27.
3
Small interfering RNA (siRNA)-mediated silencing of the M2 subunit of ribonucleotide reductase: a novel therapeutic strategy in ovarian cancer.小干扰 RNA（siRNA）介导的核苷酸还原酶 M2 亚基沉默：卵巢癌的一种新的治疗策略。
Int J Gynecol Cancer. 2013 May;23(4):659-66. doi: 10.1097/IGC.0b013e318287e2b3.
4
Bacillus anthracis thioredoxin systems, characterization and role as electron donors for ribonucleotide reductase.炭疽杆菌硫氧还蛋白系统的特性及其作为核糖核苷酸还原酶电子供体的作用。
J Biol Chem. 2012 Nov 16;287(47):39686-97. doi: 10.1074/jbc.M112.413427. Epub 2012 Sep 25.
5
Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose.谷胱甘肽和谷氧还蛋白作为人硫氧还蛋白还原酶 1 的备用酶，还原硫氧还蛋白 1，防止金硫葡萄糖引起的细胞死亡。
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Mechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species.半卡巴腙三嗪类化合物体外靶向人核苷酸还原酶及在哺乳动物细胞内的作用机制研究：酪氨酸自由基猝灭不涉及活性氧。
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Thioredoxin and thioredoxin reductase in relation to reversible S-nitrosylation.硫氧还蛋白和硫氧还蛋白还原酶与可还原的 S-亚硝基化的关系。
Antioxid Redox Signal. 2013 Jan 20;18(3):259-69. doi: 10.1089/ars.2012.4716. Epub 2012 Aug 10.
8
Inhibition of chlamydial class Ic ribonucleotide reductase by C-terminal peptides from protein R2.蛋白 R2 的 C 端肽抑制衣原体 Ic 型核糖核苷酸还原酶。
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The role of thioredoxin in the regulation of cellular processes by S-nitrosylation.硫氧还蛋白在通过S-亚硝基化调节细胞过程中的作用。
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Closing the circle on ribonucleotide reductases.核糖核苷酸还原酶研究的闭环
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硫氧还蛋白和谷氧还蛋白介导的核糖核苷酸还原酶的氧化还原调节

Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase.

作者信息

Sengupta Rajib, Holmgren Arne

机构信息

Rajib Sengupta, Arne Holmgren, Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE-17177 Stockholm, Sweden.

出版信息

World J Biol Chem. 2014 Feb 26;5(1):68-74. doi: 10.4331/wjbc.v5.i1.68.

DOI:10.4331/wjbc.v5.i1.68
PMID:24600515
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3942543/
Abstract

Ribonucleotide reductase (RNR), the rate-limiting enzyme in DNA synthesis, catalyzes reduction of the different ribonucleotides to their corresponding deoxyribonucleotides. The crucial role of RNR in DNA synthesis has made it an important target for the development of antiviral and anticancer drugs. Taking account of the recent developments in this field of research, this review focuses on the role of thioredoxin and glutaredoxin systems in the redox reactions of the RNR catalysis.

摘要

核糖核苷酸还原酶（RNR）是DNA合成中的限速酶，催化不同的核糖核苷酸还原为相应的脱氧核糖核苷酸。RNR在DNA合成中的关键作用使其成为抗病毒和抗癌药物开发的重要靶点。考虑到该研究领域的最新进展，本综述重点关注硫氧还蛋白和谷氧还蛋白系统在RNR催化的氧化还原反应中的作用。