白细胞破碎性血管炎作为心脏移植患者重组粒细胞集落刺激因子治疗的并发症。
Leukocytoclastic vasculitis as a complication of recombinant granulocyte colony-stimulating factor therapy in a heart transplant patient.
作者信息
Ippoliti Giovanbattista, Paulli Marco, Lucioni Marco, Lauriola Marinella, D'Armini Andrea Maria
机构信息
U.O Medicina Interna, Policlinico di Monza, Via C. Amati 111, 20900 Monza, Italy ; Division of Cardiac Surgery, University of Pavia School of Medicine, Foundation "I.R.C.C.S. San Matteo" Hospital, Pavia, Italy.
Anatomic Pathology, Foundation IRCCS Policlinico San Matteo, University of Pavia, Italy.
出版信息
Case Rep Transplant. 2014;2014:160407. doi: 10.1155/2014/160407. Epub 2014 Jan 30.
Abstract
Recombinant granulocyte colony-stimulating factor (rG-CSF) is a myeloid growth factor that is widely used in haematology to recover neutropenia secondary to myelosuppressive chemotherapy. Leukocytoclastic vasculitis is an acknowledged side effect of the above therapy. Its pathogenesis involves many mechanisms that collectively induce an increase in neutrophil function and a subsequent release of cytokines. Here, we report a case of leukocytoclastic vasculitis proven by skin biopsy, following the use of rG-CSF in a heart transplant patient with leukopenia secondary to immunosuppressive therapy.
摘要
重组粒细胞集落刺激因子（rG-CSF）是一种骨髓生长因子，在血液学中广泛用于恢复骨髓抑制性化疗继发的中性粒细胞减少。白细胞破碎性血管炎是上述治疗公认的副作用。其发病机制涉及多种机制，这些机制共同导致中性粒细胞功能增加并随后释放细胞因子。在此，我们报告一例经皮肤活检证实的白细胞破碎性血管炎病例，该病例发生在一名因免疫抑制治疗继发白细胞减少的心脏移植患者使用rG-CSF之后。
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