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角膜内环(INTACS SK)可能对角膜圆锥症有益;一项前瞻性非随机研究。

Intracorneal Rings (INTACS SK) Might be Beneficial in Keratoconus; A Prospective Nonrandomized Study.

作者信息

A Ibrahim Tarek, Elmor Osama

机构信息

Eye Consultants, Dubai Healthcare City, Dubai, UAE.

出版信息

Med Hypothesis Discov Innov Ophthalmol. 2013 Summer;2(2):35-40.

Abstract

In order to determine the effect of intracorneal rings (Intacs SK), when implanted in keratoconic patients, on corneal curvature, Uncorrected Visual Acuity (UCVA), Best Corrected Visual Acuity (BCVA) and on the progression of the cone through three years follow-up period. In this prospective nonrandomized study 114 eyes of 71 keratoconic patients (38 females and 33 males) were implanted with Intacs SK. Incisions were always made in the steep meridian. UCVA, BCVA, Corneal Topography (TMS) were measured pre and postoperatively and at intervals of 1, 3, 6 & 12 months then yearly for 3 consecutive years. Preoperative mean k-reading was 52.53 and 48.18, 49.56, 49.17, 48.51, 48.15 & 48.01 at 1, 3, 6, 12, 24 & 36 months postoperatively (P‹0.01). In terms of UCVA, 15.64% of patients gained more than 3 lines and 69.73% gained 1-3 lines with a total of 85.37% of patients gaining lines compared to their preoperative UCVA (P‹0.01) while 14.63% of cases did not gain any lines at 1 month postoperative. At three months postoperatively, 12.64% gained more than 3 lines, 71.15% gained 1-3 lines with a total of 83.79% while 16.21% did not gain any lines. Three years postoperative 11.82% of cases gained more than 3 lines, 73.23% gained 1-3 lines with a total of 85.05% while 14.95% did not gain any lines (P‹0.01). With regard to BCVA, 19.73% gained more than 3 lines, 68.26% gained 1-3 lines with a total of 87.99% of cases gaining lines compared to their preoperative BCVA (P‹0.01) while 12.01% did not gained any lines at 1 month postoperative. At three months postoperatively, 14.96% gained more than 3 lines, 70.19% gained 1-3 lines with a total of 85.15% while 14.85% did not gain any lines. Three years postoperative, 12.17% gained more than 3 lines, 71.78% gained 1-3 lines with a total of 83.95% (P‹0.01) while 16.05% did not gain any lines. No eyes lost any lines as it pertained to UCVA & BCVA. Despite the fluctuation of k-readings, UCVA and BCVA in the first 3 months, which may represent the time needed to stabilize the cone, UCVA and BCVA were improved and maintained throughout the study. Patient selection remains the key point for the success of intacs in keratoconic patients.

摘要

为了确定圆锥角膜患者植入角膜内环(Intacs SK)对角膜曲率、未矫正视力(UCVA)、最佳矫正视力(BCVA)以及圆锥角膜进展情况的影响,我们进行了为期三年的随访研究。在这项前瞻性非随机研究中,71例圆锥角膜患者(38例女性和33例男性)的114只眼睛植入了Intacs SK。切口均在陡峭子午线方向。术前及术后1、3、6、12个月,随后连续三年每年测量UCVA、BCVA和角膜地形图(TMS)。术前平均角膜曲率读数为52.53,术后1、3、6、12、24和36个月分别为48.18、49.56、49.17、48.51、48.15和48.01(P<0.01)。就UCVA而言,与术前UCVA相比,15.64%的患者视力提高超过3行,69.73%的患者提高1 - 3行,总计85.37%的患者视力提高(P<0.01),而术后1个月时14.63%的患者视力未提高。术后3个月,12.64%的患者视力提高超过3行,71.15%的患者提高1 - 3行,总计83.79%,16.21%的患者视力未提高。术后三年,11.82%的患者视力提高超过3行,73.23%的患者提高1 - 3行,总计85.05%,14.95%的患者视力未提高(P<0.01)。关于BCVA,与术前BCVA相比,19.73%的患者视力提高超过3行,68.26%的患者提高1 - 3行,总计87.99%的患者视力提高(P<0.01),而术后1个月时12.01%的患者视力未提高。术后3个月,14.96%的患者视力提高超过3行,70.19%的患者提高1 - 3行,总计85.15%,14.85%的患者视力未提高。术后三年,12.17%的患者视力提高超过3行,71.78%的患者提高1 - 3行,总计83.95%(P<0.01),16.05%的患者视力未提高。在UCVA和BCVA方面,没有眼睛视力下降。尽管在最初3个月角膜曲率读数、UCVA和BCVA有波动,这可能代表圆锥角膜稳定所需的时间,但在整个研究过程中UCVA和BCVA均得到改善并保持稳定。患者选择仍然是圆锥角膜患者Intacs手术成功的关键因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d4d/3939749/5bdfd568fe23/mehdiophth-2-035-g001.jpg

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