Li Xiaotao, Zhang Xiaoxia, Wei Liye, Xia Yue, Guo Xichao
Department of Cardiology, Beijing Armed Police Corps Hospital, Beijing 100027, China.
Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Science, Beijing 100029, China.
Clin Lab. 2014;60(1):113-8. doi: 10.7754/clin.lab.2013.121245.
Oncostatin M (OSM) is an inflammatory cytokine which has been found to be expressed at sites of atherosclerotic lesions. We sought to investigate whether serum OSM levels are associated with coronary stenosis in patients with coronary artery disease (CAD).
A total of 117 patients with CAD and 35 patients without CAD who underwent coronary angiography were enrolled in this study. Serum levels of OSM were measured by enzyme-linked immunosorbent assay. The severity of CAD was assessed by the number of diseased vessels and coronary stenosis score.
Serum OSM levels were significantly elevated in CAD patients compared with those without CAD. A stepwise increase in serum levels of OSM was also found depending on the number of > 50% coronary stenosis: median value 4.24 pg/mL (2.72 - 4.24) in 1-vessel disease, 6.44 pg/mL (4.87 - 10.09) in 2-vessel disease, and 7.83 pg/mL (5.41 - 10.37) in 3-vessel disease (p = 0.007 for trend). Correlation analysis showed coronary stenosis score positively correlated with age (r = 0.202, p = 0.029), current smoking (r = 0.210, p = 0.023), hypertension (r = 0.256, p = 0.005), TG (r = 0.408, p = 0.000), LDL-cholesterol (r = 0.325, p < 0.001), and hs-CRP (r = 0.307, p = 0.001), and correlated with OSM (r = 0.314, p < 0.001).
Our data suggest that increased serum OSM levels are associated with the coronary stenosis score and that circulating levels of this chemokine may reflect the extent of coronary atherosclerosis.
抑瘤素M（OSM）是一种炎症细胞因子，已发现其在动脉粥样硬化病变部位表达。我们试图研究血清OSM水平是否与冠心病（CAD）患者的冠状动脉狭窄相关。
本研究纳入了117例接受冠状动脉造影的CAD患者和35例无CAD患者。采用酶联免疫吸附测定法测量血清OSM水平。通过病变血管数量和冠状动脉狭窄评分评估CAD的严重程度。
与无CAD患者相比，CAD患者血清OSM水平显著升高。根据冠状动脉狭窄>50%的数量，还发现血清OSM水平呈逐步升高：单支血管病变时中位数为4.24 pg/mL（2.72 - 4.24），双支血管病变时为6.44 pg/mL（4.87 - 10.09），三支血管病变时为7.83 pg/mL（5.41 - 10.37）（趋势p = 0.007）。相关性分析显示冠状动脉狭窄评分与年龄呈正相关（r = 0.202，p = 0.029）、与当前吸烟呈正相关（r = 0.210，p = 0.023）、与高血压呈正相关（r = 0.256，p = 0.005）、与甘油三酯呈正相关（r = 0.408，p = 0.000）、与低密度脂蛋白胆固醇呈正相关（r = 0.325，p < 0.001）以及与超敏C反应蛋白呈正相关（r = 0.307，p = 0.001），并且与OSM呈正相关（r = 0.314，p < 0.001）。
我们的数据表明血清OSM水平升高与冠状动脉狭窄评分相关，并且这种趋化因子的循环水平可能反映冠状动脉粥样硬化的程度。
